RT info:eu-repo/semantics/article
T1 Synthesis, Crystal Structure, Spectroscopic Characterization, DFT Calculations and Cytotoxicity Assays of a New Cu(II) Complex with an Acylhydrazone Ligand Derived from Thiophene
A1 Rodríguez, María R.
A1 Balsa, Lucía M.
A1 Piro, Oscar Enrique
A1 Echeverría, Gustavo A.
A1 García Tojal, Javier
A1 Pis Diez, Reinaldo
A1 León, Ignacio E.
A1 Parajón Costa, Beatriz S.
A1 González Baró, Ana C.
K1 Copper(II) complex
K1 N-acylhydrazone
K1 Spectroscopy
K1 XRD crystal structure
K1 DFT calculations
K1 Anti-cancer activity
K1 Química inorgánica
K1 Chemistry, Inorganic
AB A new Cu(II) complex is synthetized by the reaction of copper nitrate and a N-acylhydrazone ligand obtained from the condensation of o-vanillin and 2-thiophecarbohydrazide (H2L). The solid-state structure of [Cu(HL)(H2O)](NO3)·H2O, or CuHL for simplicity, was determined by X-ray diffraction. In the cationic complex, the copper center is in a nearly squared planar environment with the nitrate interacting as a counterion. CuHL was characterized by spectroscopic techniques, including solid-state FTIR, Raman, electron paramagnetic resonance (EPR) and diffuse reflectance and solution UV-Vis electronic spectroscopy. Calculations based on the density functional theory (DFT) assisted the interpretation and assignment of the spectroscopic data. The complex does not show relevant antioxidant activity evaluated by the radical cation of 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) method, being even less active than the free ligand as a radical quencher. Cytotoxicity assays of CuHL against three human tumor cell lines, namely MG-63, A549 and HT-29, revealed an important enhancement of the effectiveness as compared with both the ligand and the free metal ion. Moreover, its cytotoxic effect was remarkably stronger than that of the reference metallodrug cisplatin in all cancer cell lines tested, a promissory result in the search for new metallodrugs of essential transition metals.
PB MDPI
YR 2021
FD 2021-01
LK http://hdl.handle.net/10259/9778
UL http://hdl.handle.net/10259/9778
LA eng
NO This research was funded by CONICET-CCT- La Plata (PIP 0651 and 034), ANPCyT (PICT 2016-1574) and UNLP (11/X041, 11/X837 and 11/X857), Argentina, and also by Consejería de Educación of Junta de Castilla y León BU022G18, Junta de Castilla y León and FEDER BU291P18 and BU049P20, Ministerio de Economía y Competitividad, CTQ2016-75023-C2-1-P, and Ministerio de Ciencia, Innovación y Universidades, CTQ(QMC) RED2018-102471-T, MultiMetDrugs Network (Spain).
DS Repositorio Institucional de la Universidad de Burgos
RD 22-dic-2024