RT info:eu-repo/semantics/article
T1 Mouse models of metastasis: progress and prospects
A1 Gómez Cuadrado, Laura
A1 Tracey, Natasha
A1 Ma, Ruoyu
A1 Qian, Binzhi
A1 Brunton, Valerie G.
K1 Cancer
K1 Metastasis
K1 Mouse models
K1 Stroma
K1 Oncología
K1 Oncology
K1 Salud
K1 Health
AB Metastasis is the spread of cancer cells from a primary tumor to distant sites within the body to establish secondary tumors. Although this is an inefficient process, the consequences are devastating as metastatic disease accounts for >90% of cancer-related deaths. The formation of metastases is the result of a series of events that allow cancer cells to escape from the primary site, survive in the lymphatic system or blood vessels, extravasate and grow at distant sites. The metastatic capacity of a tumor is determined by genetic and epigenetic changes within the cancer cells as well as contributions from cells in the tumor microenvironment. Mouse models have proven to be an important tool for unraveling the complex interactions involved in the metastatic cascade and delineating its many stages. Here, we critically appraise the strengths and weaknesses of the current mouse models and highlight the recent advances that have been made using these models in our understanding of metastasis. We also discuss the use of these models for testing potential therapies and the challenges associated with the translation of these findings into the provision of new and effective treatments for cancer patients.
PB The Company of Biologists
SN 1754-8403
YR 2017
FD 2017-09
LK http://hdl.handle.net/10259/9793
UL http://hdl.handle.net/10259/9793
LA eng
NO L.G.-C. is supported by a Cancer Research UK Edinburgh Centre training grant (C157/A25186). N.T. is funded by a Medical Research Council (MRC) training grant (MR/K50080X/1). R.M. is partially funded by a University of Edinburgh Global Research Scholarship. B.Q. is partially funded by a Cancer Research UK Career Development Fellowship (C49791/A17367) and a European Research Council Starting Grant (716379). Part of the work was undertaken in the MRC Centre for Reproductive Health, which is funded by a MRC Centre grant (MR/N022556/1). V.G.B. is partially funded by Cancer Research UK (C157/A15703) and the European Research Council (29440)
DS Repositorio Institucional de la Universidad de Burgos
RD 22-dic-2024