RT info:eu-repo/semantics/article
T1 Tridentate acylhydrazone copper(II) complexes with heterocyclic bases as coligands. Synthesis, spectroscopic studies, crystal structure and cytotoxicity assays
A1 Burgos López, Y.
A1 Balsa, Lucía M.
A1 Piro, Oscar Enrique
A1 León, Ignacio E.
A1 García Tojal, Javier
A1 Echeverría, Gustavo A.
A1 González Baró, Ana C.
A1 Parajón Costa, Beatriz S.
K1 Cu(II)-complexes
K1 Hydrazones
K1 Spectroscopy
K1 Crystal structure
K1 Anticancer activity
K1 Química analítica
K1 Chemistry, Analytic
K1 Ingeniería Química
K1 Chemical engineering
AB Two new penta-coordinated copper(II) hydrazone coordination compounds with 2,2́ bipyridine (I) or 1,10 phenanthroline (II) as coligands are synthesized and characterized in the solid state and in solution by spectroscopic methods (FTIR, Raman, UV–vis, EPR). Single crystal X-ray studies show that they have closely related molecular structures with the copper center in a distorted square pyramidal O2N3 environment. The N-acylhydrazone, 4-hydroxy-NŃ-(E)2-hydroxy-3-methoxybenzylidene]benzohydrazide, H2L, coordinates tridentate through its ONO donor atoms as monoanion (HL-) in the cationic complex (I), [Cu(HL)(bipy)](NO3). During the period that takes the synthesis reaction of compound (II), [Cu(L)(o-phen)] to complete, keto-amine to enol-imine tautomerization of H2L occurs and the hydrazone coordinates tridentate as dianionic ligand (L2-). The fivefold coordination sphere of the complexes is completed with the nitrogen atoms of the respective coligands. Cytotoxicity studies against bone (MG-63, IC50(I) = 5.6 ± 1.0 , IC50(II) = 3.5 ± 0.3), breast (MCF7, IC50(I) = 10.8 ± 1.9, IC50(II) = 4.0 ± 1.3), (MDA-MB-231, IC50(I) = 11.4 ± 0.6, IC50(II) = 5.3 ± 0.2) and lung cancer cells (A549, IC50(I) = 7.7 ± 0.7, IC50(II) = 7.0 ± 0.4) reveals increased effectiveness of both complexes compared with the free ligand, the copper nitrate salt and the reference metallodrug cisplatin (CDDP).
PB Elsevier
SN 0277-5387
YR 2022
FD 2022-02
LK http://hdl.handle.net/10259/9807
UL http://hdl.handle.net/10259/9807
LA eng
NO This work was supported by CONICET-CCT-La Plata (PIP: 0340, 0651), UNLP (Grant: 11/X673, 11/041, 11/857), ANPCyT (PICT 2016–1574), Argentina, and by Junta de Castilla y León and FEDER BU291P18 and BU049P20, Ministerio de Economía y Competitividad CTQ2016-75023-C2-1-P, Fundación Bancaria Caixa D. Etalvis I Pensions de Barcelona La Caixa-UBU001 and European Union H2020-LC-SC3-2020-NZE-RES-CC Nefertiti Project, of Spain.
DS Repositorio Institucional de la Universidad de Burgos
RD 22-feb-2025