RT info:eu-repo/semantics/article
T1 Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models
A1 Biosca-Brull, Judit
A1 Pérez Fernández, Cristian
A1 Mora, Santiago
A1 Carrillo, Beatriz
A1 Pinos, Helena
A1 Conejo, Nelida Maria
A1 Collado, Paloma
A1 Arias, Jorge L.
A1 Martín-Sánchez, Fernando
A1 Sánchez Santed, Fernando
A1 Colomina, María Teresa
K1 Autism spectrum disorder
K1 Sociability
K1 Pesticide
K1 Organophosphate
K1 Carbamates
K1 Organochlorine
K1 Chlorpyrifos
K1 Trastornos del espectro autista
K1 Autism spectrum disorders
K1 Pesticidas
K1 Pesticides
AB Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.
PB MDPI
SN 1660-4601
YR 2021
FD 2021-05
LK http://hdl.handle.net/10259/9897
UL http://hdl.handle.net/10259/9897
LA eng
NO he study was supported by grants from the Spanish Goverment (Ministerio de Economía y Competitividad, Ministerio de Ciencia, Innovación y Universidades and Instituto Mixto de Investigación-Escuela Nacional de Sanidad (IMIENS)) and the Fondo Europeo de Desarrollo Regional (MINECO-FEDER) [Grant numbers: PSI2017-86847-C2-1-R MINECO-FEDER, PSI2017-86847-C2-2-R, PSI2017-86396-P, PSI2017-90806-REDT, PSI2013-45924-P, PSI2017-83038-P, PSI2017-83893-R, MINECO PSI2017-86396-P and IMIENS: PIC-IMIENS-2018-003].
DS Repositorio Institucional de la Universidad de Burgos
RD 21-ene-2025