TY  - JOUR 
AU  - Mendes, Marta V.
AU  - Tunca, Sedef
AU  - Antón Fidalgo, Nuria
AU  - Recio, Eliseo
AU  - Sola-Landa, Alberto
AU  - Aparicio, Jesús F.
AU  - Martín, Juan F.
PY  - 2007
SN  - 1096-7176
UR  - https://hdl.handle.net/10259/12152
AB  - The biosynthesis of the antifungal pimaricin in Streptomyces natalensis is very sensitive to phosphate regulation. Concentrations of inorganic phosphate above 1 mM drastically reduced pimaricin production. At 10 mM phosphate, expression of all the...
LA  - eng
PB  - Elsevier
KW  - Pimaricin
KW  - Polyene
KW  - Polyketide synthase
KW  - Phosphate regulation
KW  - PHO boxes
KW  - PhoP
KW  - DNA binding
KW  - Genética bacteriana
KW  - Bacterial genetics
KW  - Antibióticos
KW  - Antibiotics
TI  - The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis
DO  - 10.1016/j.ymben.2006.10.003
T2  - Metabolic Engineering
VL  - 9
M2  - 217
ER  -