TY - JOUR AU - Villa Pérez, Pablo . AU - Merino, Beatriz AU - Fernández Díaz, Cristina M. . AU - Cidad, Pilar AU - Lobatón, Carmen D. AU - Moreno, Alfredo AU - Muturi, Harrison T. . AU - Ghadieh, Hilda E. . AU - Najjar, Sonia M. . AU - Leissring, Malcolm A. AU - Cózar Castellano, Irene AU - Perdomo Hernández, Germán M. PY - 2018 SN - 0026-0495 UR - http://hdl.handle.net/10259/4965 AB - The role of insulin-degrading enzyme (IDE), a metalloprotease with high affinity for insulin, in insulin clearance remains poorly understood. OBJECTIVE: This study aimed to clarify whether IDE is a major mediator of insulin clearance, and to define... LA - eng PB - Elsevier KW - nsulin-degrading enzyme KW - Hepatic insulin resistance KW - Insulin recepto KW - Carcinoembryonic antigen-related cell adhesion molecule 1 KW - Endocrinología KW - Endocrinology TI - Liver-specific ablation of insulin-degrading enzyme causes hepatic insulin resistance and glucose intolerance, without affecting insulin clearance in mice DO - 10.1016/j.metabol.2018.08.001 ER -