View Item 

Show simple item record

dc.contributor.authorDíaz de Greñu Puertas, Borja 
dc.contributor.authorGarcía Calvo, José 
dc.contributor.authorCuevas Vicario, José Vicente 
dc.contributor.authorGarcía Herbosa, Gabriel 
dc.contributor.authorGarcía Ruiz, Begoña 
dc.contributor.authorBusto Vázquez, Natalia 
dc.contributor.authorIbeas Cortes, Saturnino 
dc.contributor.authorTorroba Pérez, Tomás 
dc.contributor.authorTorroba, Blanca
dc.contributor.authorHerrera, Antonio
dc.contributor.authorPons, Sebastian
dc.date.accessioned2017-03-14T11:36:48Z
dc.date.available2017-03-14T11:36:48Z
dc.date.issued2015-07
dc.identifier.urihttp://hdl.handle.net/10259/4361
dc.description.abstractSelected new fluorogenic probes that interact in different ways with Hg2+ and MeHg+ have been prepared and used for the chemical speciation of both cations in aqueous solution as well as in HEK293 cells. The best selective speciation of Hg2+ and MeHg+ has been achieved by in vitro approaches based on fluorogenic probes supported in cultured cells, due to the particular sensitivity of the HEK293 cells to permeation by Hg2+, MeHg+ and the fluorogenic probes. In particular, MeHg+ was selectively detected in cell nuclei by probe JG45.en
dc.description.sponsorshipthe Ministerio de Econom´ıa y Competitividad, Spain (Projects CTQ2012- 31611 and CTQ2014-58812-C2-2-R), Junta de Castilla y Le´on, Consejer´ıa de Educaci´on y Cultura y Fondo Social Europeo (Project BU246A12-1), Obra Social “la Caixa” OSLC-2012-007 and the European Commission, Seventh Framework Programme (Project SNIFFER FP7-SEC-2012-312411).en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherRoyal Society of Chemistryen
dc.relation.ispartofChemical Science. 2015, V. 6, n. 7, p. 3757-3764en
dc.rightsAttribution 3.0 Unported
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subject.otherChemistry, Organicen
dc.subject.otherQuímica orgánicaes
dc.titleChemical speciation of MeHg+ and Hg2+ in aqueous solution and HEK cells nuclei by means of DNA interacting fluorogenic probesen
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttp://dx.doi.org/10.1039/C5SC00718F
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/312411
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionen


Files in this item

Thumbnail
Name:
Díaz-CHS_2015.pdf
Size:
3.364Mb
Format:
Adobe PDF
FilesOpen

This item appears in the following Collection(s)

Show simple item record