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dc.contributor.authorMartínez Alonso, Marta 
dc.contributor.authorBusto Vázquez, Natalia 
dc.contributor.authorAguirre, Larry Danilo
dc.contributor.authorBerlanga, Leticia 
dc.contributor.authorCarrión, María C. .
dc.contributor.authorCuevas Vicario, José Vicente 
dc.contributor.authorRodríguez, Ana M. .
dc.contributor.authorCarbayo Martín, Mª Aránzazu 
dc.contributor.authorManzano, Blanca R. .
dc.contributor.authorOrtí, Enrique .
dc.contributor.authorJalón, Félix A.
dc.contributor.authorGarcía Ruiz, Begoña 
dc.contributor.authorEspino Ordóñez, Gustavo 
dc.date.accessioned2018-12-04T08:45:55Z
dc.date.issued2018-11
dc.identifier.issn0947-6539
dc.identifier.urihttp://hdl.handle.net/10259/5041
dc.description.abstractIn this paper, the synthesis, comprehensive characterization and biological and photocatalytic properties of two series of neutral IrIII biscyclometalated complexes of general formula [Ir(C^N)2(N^O)], where the N^O ligands are 2‐(benzimidazolyl)phenolate‐N,O (L1, series a) and 2‐(benzothiazolyl)phenolate‐N,O (L2, series b), and the C^N ligands are 2‐(phenyl)pyridinate or its derivatives, are described,. Complexes of types a and b exhibit dissimilar photophysical and biological properties. In vitro cytotoxicity tests conclusively prove that derivatives of series a are harmless in the dark against SW480 cancer cells (colon adenocarcinoma), but express enhanced cytotoxicity versus the same cells after stimulation with UV or blue light. In contrast, complexes of type b show a very high cytotoxic activity in the dark, but low photosensitizing ability. Thus, the ancillary N^O ligand is the main factor in terms of cytotoxic activity both in the dark and upon irradiation. However, the C^N ligands play a key role regarding cellular uptake. In particular, the complex of formula [Ir(dfppy)2(L1)] (dfppy=2‐(4,6‐difluorophenyl)pyridinate) [3 a] has been identified as both an efficient photosensitizer for 1O2 generation and a potential agent for photodynamic therapy. These capabilities are probably related to a combination of its notable cellular internalization, remarkable photostability, high photoluminescence quantum yield, and long triplet excited‐state lifetime. Both types of complexes exhibit notable catalytic activity in the photooxidation of thioanisole and S‐containing aminoacids with full selectivity.en
dc.description.sponsorshipSpanishMinisteriode Econom&ayCompetitividad-FEDER(CTQ2014-58812-C2-1-Rand CTQ2014-58812-C2-2-R,CTQ2015-70371-REDT,CTQ2015-71353-R,CTQ2015-71154-P,and Unidadde Excelencia Mar&adeMaeztuMDM-2015-0538),the Conseje-r&adeEducacijn-Juntade CastillayLejn-FEDER(BU299A12-1,BU042U16and BU051U16).The Generalitat Valenciana(Prome-teo2016/135),andthe “la Caixa”Foundation(LCF/PR/PR12/11070003)en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherWiley-VCH Verlagen
dc.relation.ispartofChemistry-a european journal. 2018, V. 24, n. 66, p. 17523-17537en
dc.subject2-arylazolesen
dc.subjectanticancercomplexesen
dc.subjectheterolepticneutraliridium(III)complexesen
dc.subjectphosphorescent complexesen
dc.subjectphotodynamictherapyen
dc.subject.otherQuímicaes
dc.subject.otherChemistryen
dc.titleStrong influence of the ancillary ligand over the photodynamic anticancer properties of neutral biscyclometalated IrIII complexes bearing 2‐benzoazole‐phenolatesen
dc.typeinfo:eu-repo/semantics/article
dc.date.embargo2019-11-27
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://doi.org/10.1002/chem.201803784
dc.identifier.doi10.1002/chem.201803784
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/CTQ2014-58812-C2-1-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/CTQ2014-58812-C2-2-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/CTQ2015-70371-REDT
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/CTQ2015-71353-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/CTQ2015-71154-P
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/MDM-2015-0538
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU299A12-1
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU042U16
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU051U16
dc.relation.projectIDinfo:eu-repo/grantAgreement/GVA/Prometeo2016-135
dc.relation.projectIDinfo:eu-repo/grantAgreement/FundaciónLaCaixa/LCF-PR-PR12-11070003
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersionen


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