Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/5213
Título
Gold(i)-catalyzed nucleophilic cyclization of β-monosubstituted o-(alkynyl)styrenes: a combined experimental and computational study
Autor
Publicado en
Organic & Biomolecular Chemistry. 2019, V. 17, n. 46, p. 9924-9932
Editorial
Royal Society of Chemistry
Fecha de publicación
2019-12
ISSN
1477-0520
DOI
10.1039/C9OB02126D
Zusammenfassung
The stereospecific gold(I)-catalyzed nucleophilic cyclization of β-monosubstituted o-(alkynyl)styrenes to produce C-1 functionalized 1H-indenes including challenging substrates and nucleophiles, such as β-(cyclo)alkyl-substituted o-(alkynyl)styrenes and a variety of alcohols as well as selected electron-rich aromatics, is reported. DFT calculations support the stereochemical outcome of the process that involves the formation of a key cyclopropyl gold carbene intermediate through a regiospecific 5-endo cyclization.
Materia
Química orgánica
Chemistry, Organic
Versión del editor
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