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dc.contributor.authorPerdomo Hernández, Germán M. 
dc.contributor.authorMerino, Beatriz
dc.contributor.authorFernández Díaz, Cristina M. .
dc.contributor.authorCózar Castellano, Irene
dc.date.accessioned2020-03-13T09:13:36Z
dc.date.available2020-03-13T09:13:36Z
dc.date.issued2020-01
dc.identifier.urihttp://hdl.handle.net/10259/5242
dc.description.abstractThe worldwide epidemics of obesity and diabetes have been linked to increased sugar consumption in humans. Here, we review fructose and glucose metabolism, as well as potential molecular mechanisms by which excessive sugar consumption is associated to metabolic diseases and insulin resistance in humans. To this end, we focus on understanding molecular and cellular mechanisms of fructose and glucose transport and sensing in the intestine, the intracellular signaling effects of dietary sugar metabolism, and its impact on glucose homeostasis in health and disease. Finally, the peripheral and central effects of dietary sugars on the gut–brain axis will be reviewed.en
dc.description.sponsorshipSpanish MINISTERIO DE ECONOMÍA, INDUSTRIA Y COMPETITIVIDAD, grant numbers SAF2016-77871-C2-1-R and SAF2016-77871-C2-2-R to I.C-C. and G.P. respectively; the EFSD European Research Programme on New Targets for Type 2 Diabetes supported by an educational research grant from MSD to I.C-C. and G.P.; the FUNDACIÓN LA-CAIXA Y FUNDACIÓN CAJA DE BURGOS, grant number CAIXA-UBU001 to G.P.es
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofNutrients. 2020, V. 12, n. 1, 94es
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectfructoseen
dc.subjectglucoseen
dc.subjectsmall intestineen
dc.subjectliveren
dc.subjectbrainen
dc.subjectgut-brain axisen
dc.subjectnon-alcoholic fatty liveren
dc.subjectinsulin resistanceen
dc.subjectmetabolic syndromeen
dc.subjecttype 2 diabetes mellitusen
dc.subject.otherEndocrinologíaes
dc.subject.otherEndocrinologyen
dc.titleIntestinal fructose and glucose metabolism in health and diseaseen
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://doi.org/10.3390/nu12010094es
dc.identifier.doi10.3390/nu12010094
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/SAF2016-77871-C2-1-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/SAF2016-77871-C2-2-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/FundaciónLaCaixa/CAIXA-UBU001
dc.identifier.essn2072-6643
dc.journal.titleNutrientses
dc.volume.number12es
dc.issue.number1es
dc.page.initial94es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion


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