Zur Kurzanzeige

dc.contributor.authorAlcaraz, Raquel
dc.contributor.authorMuñiz Rodríguez, Pilar 
dc.contributor.authorCavia Saiz, Mónica 
dc.contributor.authorPalacios, Óscar
dc.contributor.authorSamper, Katia G.
dc.contributor.authorGil García, Rubén 
dc.contributor.authorJiménez Pérez, Alondra 
dc.contributor.authorGarcía Tojal, Javier 
dc.contributor.authorGarcía Girón, Carlos
dc.date.accessioned2020-06-01T15:15:44Z
dc.date.available2020-06-01T15:15:44Z
dc.date.issued2020-05
dc.identifier.issn0162-0134
dc.identifier.urihttp://hdl.handle.net/10259/5318
dc.description.abstractColorectal cancer is the third most common type of cancer and has a high incidence in developed countries. At present, specific treatments are being required to allow individualized therapy depending on the molecular alteration on which the drug may act. The aim of this project is to evaluate whether HPTSC and HPTSC* thiosemicarbazones (HPTSC = pyridine-2-carbaldehyde thiosemicarbazone and HPTSC* = pyridine-2-carbaldehyde 4N-methylthiosemicarbazone), and their complexes with different transition metal ions as Cu(II), Fe(III) and Co(III), have antitumor activity in colon cancer cells (HT-29 and SW-480), that have different oncogenic characteristics. Cytotoxicity was evaluated and the involvement of oxidative stress in its mechanism of action was analyzed by quantifying the superoxide dismutase activity, redox state by quantification of the thioredoxin levels and reduced/oxidized glutathione rate and biomolecules damage. The apoptotic effect was evaluated by measurements of the levels of caspase 9 and 3 and the index of histones. All the metal-thiosemicarbazones have antitumor activity mediated by oxidative stress. The HPTSC*-Cu was the compound that showed the best antitumor and apoptotic characteristics for the cell line SW480, that is KRAS gene mutated.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofJournal of Inorganic Biochemistry. 2020, V. 206, 110993es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCell deathen
dc.subjectCobalt compoundsen
dc.subjectColon carcinomaen
dc.subjectIron compoundsen
dc.subjectOxidative stressen
dc.subjectThiosemicarbazoneen
dc.subject.otherBioquímicaes
dc.subject.otherBiochemistryen
dc.titleThiosemicarbazone-metal complexes exhibiting cytotoxicity in colon cancer cell lines through oxidative stressen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1016/j.jinorgbio.2020.110993es
dc.identifier.doi10.1016/j.jinorgbio.2020.110993
dc.journal.titleJournal of Inorganic Biochemistryes
dc.volume.number206es
dc.page.initial110993es
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones


Dateien zu dieser Ressource

Thumbnail

Das Dokument erscheint in:

Zur Kurzanzeige