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dc.contributor.authorDomi, Brixhilda 
dc.contributor.authorBhorkar, Kapil
dc.contributor.authorRumbo Lorenzo, Carlos 
dc.contributor.authorSygellou, Labrini
dc.contributor.authorYannopoulos, Spyros N.
dc.contributor.authorQuesada Pato, Roberto 
dc.contributor.authorTamayo Ramos, Juan Antonio 
dc.date.accessioned2020-09-24T09:52:56Z
dc.date.available2020-09-24T09:52:56Z
dc.date.issued2020-10
dc.identifier.issn0957-4484
dc.identifier.urihttp://hdl.handle.net/10259/5483
dc.description.abstractThe physicochemical properties and the toxicological potential of commercially available MoS2 nanoparticles with different lateral size and degradation stage were studied in the present research work. To achieve this, the structure and stoichiometry of fresh and old aqueous suspensions of micro-MoS2 and nano-MoS2 was analyzed by Raman, while x-ray photoelectron spectroscopy allowed to identify more quantitatively the nature of the formed oxidized species. A, the toxicological impact of the nanomaterials under analysis was studied using adenocarcinomic human alveolar basal epithelial cells (A549 cells) and the unicellular fungus S. cerevisiae as biological models. Cell viability assays and reactive oxygen species (ROS) determinations demonstrated different toxicity levels depending on the cellular model used and in function of the degradation state of the selected commercial nanoproducts. Both MoS2 nanoparticle types induced sublethal damage on the A549 cells though the increase of intracellular ROS levels, while comparable concentrations reduced the viability of yeast cells. In addition, the old MoS2 nanoparticles suspensions exhibited a higher toxicity for both human and yeast cells than the fresh ones. Our findings demonstrate that the fate assessment of nanomaterials is a critical aspect to increase the understanding on their characteristics and on their potential impact on biological systems along their life cycle.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherIOP Publishinges
dc.relation.ispartofNanotechnology, 2020. V. 31, N. 44, 445101es
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectmolybdenum disulfideen
dc.subjectnanoparticlesen
dc.subjectfateen
dc.subjectphysicochemical compositionen
dc.subjecttoxicityen
dc.subjectoxidative stressen
dc.subjectcell viabilityen
dc.subject.otherQuímica orgánicaes
dc.subject.otherChemistry, Organicen
dc.titleFate assessment of commercial 2D MoS2 aqueous dispersions at physicochemical and toxicological levelen
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://doi.org/10.1088/1361-6528/aba6b3es
dc.identifier.doi10.1088/1361-6528/aba6b3
dc.identifier.essn1361-6528
dc.journal.titleNanotechnologyes
dc.volume.number31es
dc.issue.number44es
dc.page.initial445101es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion


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