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dc.contributor.authorRoque Viadas, Lara
dc.contributor.authorFernández López, María
dc.contributor.authorBenito Moreno, José Manuel 
dc.contributor.authorEscudero Barbero, Isabel 
dc.date.accessioned2020-10-15T08:06:58Z
dc.date.available2020-10-15T08:06:58Z
dc.date.issued2020-09
dc.identifier.issn0927-7757
dc.identifier.urihttp://hdl.handle.net/10259/5516
dc.description.abstractThis work reports the study of surface and aggregation properties of formulations containing mixed niosomes of the non-ionic surfactant sorbitan monooleate (Span 80) and the cationic surfactant cetyltrimethylammonium bromide (CTAB), in concentrations of 20 and 4 mol/m3, respectively, in salt-free water and in the presence of NaCl (20, 50 and 80 mol/m3). The aim of this work was the formulation of stable Span 80 and CTAB mixed niosomes with low surfactant concentration. The mixed niosomes were prepared by ultrasonication and their properties (surface tension, particle size distribution, ζ-potential, stability over time and morphology) were measured using different techniques. Data were analyzed and compared with those of the individual surfactants. Experimental results show that the addition of salt decreased the critical micelle concentration (CMC) and the surface tension of the surfactant dispersions with relation to their free-salt formulations. The presence of CTAB in the mixed niosome bilayer decreased the particle size and increased the stability of the mixed niosomes in all the formulations studied, compared with those of single Span 80. Synergism between both surfactants was obtained in the formation of niosome bilayers for formulations in pure water and with 20 and 50 mol/m3 of salt, while antagonism was observed in that of 80 mol/m3 NaCl. These results may allow the use of CTAB adsorbed on mixed niosomes in industrial applications, taking advantage of its antiseptic and antibacterial properties and solving the limitation imposed by its high Krafft temperature.en
dc.description.sponsorshipJunta de Castilla y León and the European Regional Development Fund (ERDF) through project BU301P18.es
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofColloids and Surfaces A: Physicochemical and Engineering Aspects. 2020, V. 601, 124999es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNiosomesen
dc.subjectSpan 80en
dc.subjectCTABen
dc.subjectSurfactantsen
dc.subjectStabilityen
dc.subjectSynergismen
dc.subject.otherIngeniería químicaes
dc.subject.otherChemical engineeringen
dc.titleStability and characterization studies of Span 80 niosomes modified with CTAB in the presence of NaClen
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://doi.org/10.1016/j.colsurfa.2020.124999
dc.identifier.doi10.1016/j.colsurfa.2020.124999
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU301P18
dc.journal.titleColloids and Surfaces A: Physicochemical and Engineering Aspectses
dc.volume.number601es
dc.page.initial124999es
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion


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