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dc.contributor.authorMelgosa Gómez, Rodrigo 
dc.contributor.authorSanz Díez, Mª Teresa 
dc.contributor.authorBeltrán Calvo, Sagrario 
dc.date.accessioned2020-12-10T12:11:04Z
dc.date.available2020-12-10T12:11:04Z
dc.date.issued2021-02
dc.identifier.issn0896-8446
dc.identifier.urihttp://hdl.handle.net/10259/5576
dc.description.abstractDriven by growing prevalence of chronic diseases and consumer’s health awareness, food supplements and nutraceuticals based on omega-3 polyunsaturated fatty acids (PUFAs) are extensively marketed nowadays. However, commercial omega-3 concentrates still present quality issues related to their purity, bioavailability, and easily-oxidizable nature, compelling the industry to seek for more efficient extraction, concentration and formulation methods. Technologies based on the use of supercritical CO2 (scCO2) are a promising alternative, replacing conventional organic solvents and providing milder conditions and an inert atmosphere, which reduce the risk of oxidation. The present review analyzes the latest advances on the use of scCO2 for processing omega-3 PUFAs, focusing on its application in biorefinery strategies for the valorization of fish by-products. Still, further research on process fundamentals is necessary in order to increase the omega-3 yield and purity while reducing the use of energy and auxiliary materials, especially in the transesterification and concentration steps.en
dc.description.sponsorshippanish Agencia Estatal de Investigación [grant number PID2019-539 104950RB-I00 / AEI / 10.13039/501100011033] and the Junta de Castilla y León (JCyL) and the European Regional Development Fund (ERDF) [grant number BU301P18 and BU050P20].es
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofThe Journal of Supercritical Fluids. 2020, V. 169, 105121es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFish oilen
dc.subjectOmega-3 polyunsaturated fatty acidsen
dc.subjectBiorefineryen
dc.subjectSupercritical carbon dioxideen
dc.subjectEnzymeen
dc.subject.otherIngeniería químicaes
dc.subject.otherChemical engineeringen
dc.subject.otherAlimentoses
dc.subject.otherFooden
dc.titleSupercritical CO2 processing of omega-3 polyunsaturated fatty acids – Towards a biorefinery for fish waste valorizationen
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://doi.org/10.1016/j.supflu.2020.105121
dc.identifier.doi10.1016/j.supflu.2020.105121
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/PID2019-539 104950RB-I00 / AEI / 10.13039/501100011033
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU301P18
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU050P20
dc.journal.titleThe Journal of Supercritical Fluidses
dc.volume.number169es
dc.page.initial105121es
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion


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