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dc.contributor.authorOtt, Colby E.
dc.contributor.authorCunha Silva, Hugo 
dc.contributor.authorKuberski, Sara L
dc.contributor.authorCox, Joseph A.
dc.contributor.authorArcos Martínez, Julia 
dc.contributor.authorArroyo Mora, Luís E.
dc.date.accessioned2021-01-13T12:38:52Z
dc.date.available2021-01-13T12:38:52Z
dc.date.issued2020-09
dc.identifier.issn1572-6657
dc.identifier.urihttp://hdl.handle.net/10259/5597
dc.description.abstractSquare-wave adsorptive stripping voltammetry (SWAdSV) is proposed as a fast, simple, and sensitive approach toward the detection, identification, and semi-quantitation of fentanyl in seized drug samples using screen-printed carbon electrodes. Electrochemical oxidation of fentanyl resulted in the formation of two anodic peaks, one at 0.75 V (peak I) and the second at 0.88 V (peak II) versus a Ag/AgCl pseudo reference electrode. Voltammetric measurements were conducted under optimized experimental conditions using fentanyl standards ranging from 0.076 μg/mL to 6.9 μg/mL, which resulted in a limit of detection of 0.037 μg/mL. Reproducibility was assessed as the average percent relative standard deviation of the slopes of calibration curves and was 2.6% for oxidation peak I and 7.4% for oxidation peak II in cell. Detection capabilities were assessed in a 5-mL cell and in a 100 microliter drop. Interference studies were conducted with cocaine, methamphetamine, quinine, caffeine, and acetaminophen. The mechanism for the electrochemical oxidation of fentanyl to norfentanyl is also described. Accuracy and suitability of the method for seized drug analysis was assessed using 11 simulated samples. Suitability of the method for future analysis of fentanyl in oral fluid was assessed.en
dc.description.sponsorshipAwa the National Institute of Justice award 2019-DU-BX-0030. The opinions, findings and conclusions are those of the authors and do not necessarily reflects those of the Department of Justice. Funding was also provided by the Fundación Bancaria Caixa D. Estalvis I Pensions de Barcelona, La Caixa (DIABO-PIF-R00W05). Hugo Cunha-Silva would like to acknowledge funding from the Spanish Ministry of Economy and the European Regional Development Fund (FEDER) (BES-2014-068214).es
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofJournal of Electroanalytical Chemistry. 2020, V. 873, 114425es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFentanylen
dc.subjectScreen-printed electrodesFentanyl voltammetric determinationen
dc.subjectForensic scienceen
dc.subjectOral fluiden
dc.subjectSeized drugsen
dc.subject.otherQuímica analíticaes
dc.subject.otherChemistry, Analyticen
dc.titleElectrochemical detection of fentanyl with screen-printed carbon electrodes using square-wave adsorptive stripping voltammetry for forensic applicationsen
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://doi.org/10.1016/j.jelechem.2020.114425
dc.identifier.doi10.1016/j.jelechem.2020.114425
dc.journal.titleJournal of Electroanalytical Chemistryes
dc.volume.number873es
dc.page.initial114425es
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion


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