Mostra i principali dati dell'item

dc.contributor.authorArce Antón, Mar 
dc.contributor.authorRuiz Miguel, Santiago 
dc.contributor.authorSanllorente Méndez, Silvia 
dc.contributor.authorOrtiz Fernández, Mª Cruz 
dc.contributor.authorSarabia Peinador, Luis Antonio 
dc.contributor.authorSánchez Pastor, Mª Sagrario 
dc.date.accessioned2021-03-01T13:02:34Z
dc.date.available2021-03-01T13:02:34Z
dc.date.issued2021
dc.identifier.issn0003-2670
dc.identifier.urihttp://hdl.handle.net/10259/5631
dc.description.abstractThe paper shows a procedure for selecting the control method parameters (factors) to obtain a preset ‘analytical target profile’ when a liquid chromatographic technique is going to be carried out for the simultaneous determination of five bisphenols (bisphenol-A, bisphenol-S, bisphenol-F, bisphenol-Z and bisphenol-AF), some of them regulated by the European Union. The procedure has three steps. The first consists of building a D-optimal combined design (mixture-process design) for the control method parameters, which are the composition of the ternary mobile phase and its flow rate. The second step is to fit a PLS2 model to predict six analytical responses (namely, the resolution between each pair of consecutive peaks, and the initial and final chromatographic time) as a function of the control method parameters. The third final step is the inversion of the PLS2 model to obtain the conditions needed for attaining a preset analytical target profile. The computational inversion of the PLS2 prediction model looking for the Pareto front of these six responses provides a set of experimental conditions to conduct the chromatographic determination, specifically 22% of water, mixed with 58% methanol and 20% of acetonitrile, keeping the flow rate at 0.66 mL min−1. These conditions give a chromatogram with retention times of 2.180, 2.452, 2.764, 3.249 and 3.775 min for BPS, BPF, BPA, BPAF and BPZ, respectively, and excellent resolution among all the chromatographic peaks. Finally, the analytical method is validated under the selected experimental conditions, in terms of trueness and precision. In addition, the detection capability for the five bisphenols were: 596, 334, 424, 458 and 1156 μg L−1, with probabilities of false positive and of false negative equal to 0.05.en
dc.description.sponsorshipSpanish MINECO (AEI/FEDER, UE) and Consejería de Educación de la JCyL through projects CTQ2017-88894-R and BU052P20, co-financed with European Regional Development Fundses
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofAnalytica Chimica Acta. 2021, V. 1149, 338217es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectProcess analytical technologyen
dc.subjectPartial least squaresen
dc.subjectPareto optimalityen
dc.subjectBisphenol AHPLC-DADen
dc.subjectComputational latent variable model inversionen
dc.subject.otherQuímica analíticaes
dc.subject.otherChemistry, Analyticen
dc.titleA new approach based on inversion of a partial least squares model searching for a preset analytical target profile. Application to the determination of five bisphenols by liquid chromatography with diode array detectoren
dc.typeinfo:eu-repo/semantics/article
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.relation.publisherversionhttps://doi.org/10.1016/j.aca.2021.338217es
dc.identifier.doi10.1016/j.aca.2021.338217
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2017-88894-R/ES/NUEVAS HERRAMIENTAS QUIMIOMETRICAS CON VARIABLES LATENTES PARA LA TOMA DE DECISIONES EN TECNOLOGIA ANALITICA DE PROCESOS Y EN CONTEXTOS REGULADOS DE SEGURIDAD ALIMENTARIAes
dc.relation.projectIDinfo:eu-repo/grantAgreement/Junta de Castilla y León//BU052P20//Nuevos desarrollos metodológicos del diseño de experimentos para análisis químicos, bioquímicos y en tecnología analítica de procesoses
dc.journal.titleAnalytica Chimica Actaes
dc.volume.number1149es
dc.page.initial338217es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion


Files in questo item

Thumbnail

Questo item appare nelle seguenti collezioni

Mostra i principali dati dell'item