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dc.contributor.authorOrtega, Enrique
dc.contributor.authorPérez Arnáiz, Cristina 
dc.contributor.authorRodríguez, Venancio
dc.contributor.authorJaniak, Christoph
dc.contributor.authorBusto Vázquez, Natalia 
dc.contributor.authorGarcía Ruiz, Begoña 
dc.contributor.authorRuiz, José
dc.date.accessioned2021-06-24T08:14:52Z
dc.date.available2021-06-24T08:14:52Z
dc.date.issued2021-10
dc.identifier.issn0223-5234
dc.identifier.urihttp://hdl.handle.net/10259/5814
dc.description.abstractCancer and antibiotic resistance are two global health threats that usually hamper clinical chemotherapeutic efficacy. Particularly for lung cancer, bacterial infections frequently arise thereby complicating the course of cancer treatment. In this sense, three new neutral luminescent cycloplatinated(II) photosensitizers of the type [Pt(dmba)(L)] (dmba = N,N-dimethylbenzylamine-κN,κC; L = 2-(benzo[d]oxazol-2-yl)-phenolato-κN,κO 1, 2-(benzo[d]thiazol-2-yl)-phenolato-κN,κO 2, and 2-(1-methyl-1H-benzo[d]imidazole-2-yl)phenolato-κN,κO 3) have been characterized and developed to potentially eliminate both resistant bacteria and lung cancer cells. The phototherapeutic effects of complex 2 have been evaluated using low doses of blue light irradiation. Complex 2 exerted promising photoactivity against pathogenic Gram-positive bacteria strains of clinical interest, displaying a phototoxic index (PI) of 15 for methicillin-resistant Staphylococcus aureus, one of the major microorganisms predominating lung infections. Likewise, the anticancer activity of 2 was also increased upon light irradiation in human lung A549 cancer cells (PI = 36). Further in vitro experiments with this platinum(II) complex suggest that ROS-generating photodynamic reactions were involved upon light irradiation, thus providing a reasonable mechanism for its dual anticancer and antibacterial activities.en
dc.description.sponsorshipSpanish Ministerio de Ciencia e Innovación (MCI/AEI) and FEDER funds (Projects RTI2018-096891-B-I00, RTI2018-102040-B-100 and MultiMetDrugs network RED2018-102471-T), Consejería de Educación-Junta de Castilla y León-FEDER (BU042U16-BU305P18), “la Caixa” Banking Foundation (LCF/PR/PR12/11070003) and Fundación Séneca-Región de Murcia (Project 20857/PI/18). E.O. thanks AECC (PRDMU19003ORTE). Networking support by the COST Action CA18202es
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofEuropean Journal of Medicinal Chemistry. 2021, V. 222, 113600es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPlatinum(II) complexesen
dc.subjectAnticancer and antibacterial activityen
dc.subjectPhotodynamic inhibitionen
dc.subjectPhotodynamic therapyen
dc.subjectDual action agentsen
dc.subject.otherQuímica físicaes
dc.subject.otherChemistry, Physical and theoreticalen
dc.titleA 2-(benzothiazol-2-yl)-phenolato platinum(II) complex as potential photosensitizer for combating bacterial infections in lung cancer chemotherapy†en
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1016/j.ejmech.2021.113600es
dc.identifier.doi10.1016/j.ejmech.2021.113600
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN/RTI2018-096891-B-I00
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN/RTI2018-102040-B-100
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN/RED2018-102471-T
dc.relation.projectIDinfo:eu-repo/grantAgreement/JCyL/BU042U16-BU305P18
dc.relation.projectIDinfo:eu-repo/grantAgreement/FundaciónLaCaixa/LCF/PR/PR12/11070003
dc.relation.projectIDinfo:eu-repo/grantAgreement/FundaciónSeneca/20857/PI/18
dc.journal.titleEuropean Journal of Medicinal Chemistryes
dc.volume.number222es
dc.page.initial113600es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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