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dc.contributor.authorBresciani, Giulio
dc.contributor.authorBusto Vázquez, Natalia 
dc.contributor.authorCeccherini, Valentina
dc.contributor.authorBortoluzzi, Marco
dc.contributor.authorPampaloni, Guido
dc.contributor.authorGarcía Ruiz, Begoña 
dc.contributor.authorMarchetti, Fabio
dc.date.accessioned2021-12-02T10:24:43Z
dc.date.available2021-12-02T10:24:43Z
dc.date.issued2022-02
dc.identifier.issn0162-0134
dc.identifier.urihttp://hdl.handle.net/10259/6255
dc.description.abstractWe report a screening study aimed to assess for the first time the air- and water-stability and the biological potential of simple metal-carbamates. These molecular metallic species are based on elements belonging to the groups 4–5, 7–9 and 11, and tin, and are easily available from inexpensive reagents. Complexes [Ag(O2CNEt2)] (13-Ag) and [Au(O2CNMe2)(PPh3)] (14-Au) resulted substantially stable in aqueous media and exhibited a potent in vitro cytotoxicity. Especially 13-Ag revealed a significant selectivity against the A549 lung adenocarcinoma and the A2780 ovarian cancer cell lines with respect to the noncancerous HEK293 cell line. Generation of ROS (reactive oxygen species) and mitochondrial membrane depolarization were recognized for 13-Ag and 14-Au; notwithstanding, the cell death mechanism is different in the two cases: apoptosis and cell cycle arrest in G0/G1 phase for 13-Ag; necroptosis and cell cycle arrest in S phase for 14-Au. Both 13-Ag and 14-Au are endowed with antibacterial activity, which is relatively stronger for 13-Ag towards Gram negative and for 14-Au towards Gram positive strains, respectively.en
dc.description.sponsorshipLa Caixa Foundation (LCF/PR/PR12/11070003), Consejería de Educación-Junta de Castilla y León-FEDER Funds (BU305P18), Ministerio de Ciencia, Innovación y Universidades (RTI2018-102040-B-100) and the University of Pisa (PRA_2020_39).en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofJournal of Inorganic Biochemistry. 2022, V. 227, 111667en
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMetals in medicineen
dc.subjectAnticancer metal complexesen
dc.subjectTransition metal complexesen
dc.subjectMetal carbamatesen
dc.subjectCytotoxicityen
dc.subjectAntibacterial activityen
dc.subject.otherQuímica inorgánicaes
dc.subject.otherChemistry, Inorganicen
dc.subject.otherBioquímicaes
dc.subject.otherBiochemistryen
dc.titleScreening the biological properties of transition metal carbamates reveals gold(I) and silver(I) complexes as potent cytotoxic and antimicrobial agentsen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1016/j.jinorgbio.2021.111667es
dc.identifier.doi10.1016/j.jinorgbio.2021.111667
dc.relation.projectIDinfo:eu-repo/grantAgreement/Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona//LCF%2FPR%2FPR12%2F11070003
dc.relation.projectIDinfo:eu-repo/grantAgreement/Junta de Castilla y León//BU305P18
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-102040-B-I00/ES/PROPIEDADES ANTIMICROBIANAS DE NUEVOS COMPLEJOS ORGANOMETALICOSes
dc.relation.projectIDinfo:eu-repo/grantAgreement/University of Pisa//PRA_2020_39
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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