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dc.contributor.authorPicci, Giacomo
dc.contributor.authorCarreira Barral, Israel 
dc.contributor.authorAlonso Carrillo, Daniel 
dc.contributor.authorBusonera, Chiara
dc.contributor.authorMilia, Jessica
dc.contributor.authorQuesada Pato, Roberto 
dc.contributor.authorCaltagirone, Claudia
dc.date.accessioned2022-10-06T09:29:20Z
dc.date.available2022-10-06T09:29:20Z
dc.date.issued2022-09
dc.identifier.issn1477-0520
dc.identifier.urihttp://hdl.handle.net/10259/7085
dc.description.abstractA new family of squaramide-based anionophores (L1–L8) have been synthesised and fully characterised with the aim to investigate the effect of indolyl substituents on their anion binding and transmembrane transport properties. L1, L2, L6, and L8, bearing a 7-indolyl/indol-7-yl moiety as the substituent, were found to be the most efficient of the series in binding chloride with high stability constants. L1, L6, and L8 were also found to be the most potent anionophores of the series, able to mediate transmembrane anion transport. In particular, L6 bearing the 3,5-bis(trifluoromethyl)phenyl group was found to be the most active transporter, and its efficiency as an anionophore/anion transporter was favourably compared with that of their symmetrically-substituted squaramide analogues L9 and L10, previously reported in the literature.en
dc.description.sponsorshipConsejería de Educación de la Junta de Castilla y León (project BU067P20) and the Ministerio de Ciencia e Innovación (project PID2020-117610RB-I00). I. C.-B. and D. A.-C. thank the Consejería de Educación de la Junta de Castilla y León, the European Social Fund (ESF) and the European Regional Development Fund (ERDF) for their post-doctoral (I. C.-B.) and pre-doctoral (D. A.-C.) contracts. The authors gratefully acknowledge Andrea Sancho-Medina for her contributions to transmembrane anion transport experiments. Financial support from MIUR (PRIN 2017 project 2017EKCS35) is gratefully acknowledged by C. C. and G. P. along with the Università degli Studi di Cagliari (FIR 2016-2019) and the Fondazione di Sardegna (FdS Progetti Biennali di Ateneo, annualità 2020, project F75F21001260007).en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherRoyal Society of Chemistryen
dc.relation.ispartofOrganic & Biomolecular Chemistry. 2022,en
dc.rightsAttribution-NonCommercial 3.0 Unported*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/*
dc.subject.otherQuímica orgánicaes
dc.subject.otherChemistry, Organicen
dc.subject.otherBioquímicaes
dc.subject.otherBiochemistryen
dc.titleThe role of indolyl substituents in squaramide-based anionophoresen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1039/D2OB01444Kes
dc.identifier.doi10.1039/D2OB01444K
dc.relation.projectIDinfo:eu-repo/grantAgreement/Junta de Castilla y León//BU067P20es
dc.relation.projectIDinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-117610RB-I00/ES/SMALL MOLECULE TRANSMEMBRANE ANION CARRIERS FOR BIOLOGICAL APPLICATIONSes
dc.relation.projectIDinfo:eu-repo/grantAgreement/MIUR//2017EKCS35es
dc.relation.projectIDinfo:eu-repo/grantAgreement/Università degli Studi di Cagliari//FIR 2016-2019es
dc.relation.projectIDinfo:eu-repo/grantAgreement/Fondazione di Sardegna//F75F21001260007es
dc.identifier.essn1477-0539
dc.journal.titleOrganic & Biomolecular Chemistryen
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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