This work shows the potential of modified screen-printed carbon electrodes (SPCEs) for sensitive and selective
detection of 4-ethylphenol in wine. Gold nanoparticles (AuNPs) and fullerene C60 (C60), modified sensors have
been compared. pH of the supporting electrolyte, deposition time and working temperature have been optimized
considering their influence in the voltammetric pulse response of 4-ethylphenol. Under the optimal conditions of
measurement, the developed activated C60/SPCE (AC60/SPCE) shows the best performance, with a detection
capability of 400 μg/L and 700 μg/L, when using deposition times of 14 min and 6 min, respectively (α = β =
0.05). The reproducibility of the developed sensor resulted better when a deposition time of 6 min was used (5.4
%, n = 3). The influence of different interferents on the analytical response has been studied, as well as their
application in the determination of 4-ethylphenol in different wine samples.
