dc.contributor.author | Fernández-Lázaro, Diego | |
dc.contributor.author | García Hernández, Juan Luis | |
dc.contributor.author | Lumbreras, Eva | |
dc.contributor.author | Mielgo Ayuso, Juan | |
dc.contributor.author | Seco-Calvo, Jesús | |
dc.date.accessioned | 2023-03-22T08:25:38Z | |
dc.date.available | 2023-03-22T08:25:38Z | |
dc.date.issued | 2022-10 | |
dc.identifier.uri | http://hdl.handle.net/10259/7579 | |
dc.description.abstract | Sarcopenia (Sp) is the loss of skeletal muscle mass associated with aging that results in
an involution of muscle function and strength. Vitamin D deficiency is a common health problem
worldwide, especially among the elderly, and hypovitaminosis D leads to musculoskeletal disorders.
The aim of this study was to evaluate the impact and presence of a possible linkage between Single
Nucleotide Polymorphisms (SNPs) CYP2R1 (rs10741657), GC (rs2282679), and VDR (rs2228570),
serum 25-OH/D concentrations and the link with the degree of sarcopenia in 19 institutionalized
elderly men not supplemented with vitamin D. Levels of 25-OH vitamin D were quantified with
a commercial enzyme-linked immunosorbent assay kit and 3 SNPs were genotyped with KASPar
assays. Significant differences in 25-OH/D concentration were determined between the bi-allelic
combinations of rs228679 and rs228570. We detected statistically significant weak positive correlations
between the AA (rs10741657 and rs228570) and TT (rs228679) and alleles and 25-OH/D and the
probability of having higher 25-OH/D concentrations was 2- to 3-fold higher. However, the GG
alleles of the 3 SNPs showed that the probability of having optimal 25-0H/D concentrations decreases
by 32% for rs10741657, 38% for rs228679, and 74% for rs228570, showing a strong negative correlation
between the degree of sarcopenia and 25-OH/D levels. Allelic variations in CYP2R1 (rs10741657),
GC (rs2282679), and VDR (rs10741657) affect vitamin D levels and decisively influence the degree of
sarcopenia in institutionalized elderly people. | en |
dc.description.sponsorship | This research has been funded by the Chair of Knowledge and Innovation “Caja Rural de Soria” University of Valladolid Campus de Soria, Soria (Spain) in the call for funding research projects with project number SO-1-2020. D.F.-L. and J.M.-A. were members of the research team. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | es |
dc.publisher | MDPI | en |
dc.relation.ispartof | International Journal of Molecular Sciences. 2022, V. 23, n. 19, 11846 | en |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Elderly | en |
dc.subject | Aging | en |
dc.subject | Sarcopenia | en |
dc.subject | 25-OH vitamin D | en |
dc.subject | Deficiency | en |
dc.subject | Genetics | en |
dc.subject | CYP2R1 | en |
dc.subject | GC | en |
dc.subject | VDR | en |
dc.subject.other | Fisiología | es |
dc.subject.other | Physiology | en |
dc.title | 25-Hydroxyvitamin D Serum Levels Linked to Single Nucleotide Polymorphisms (SNPs) (rs2228570, rs2282679, rs10741657) in Skeletal Muscle Aging in Institutionalized Elderly Men Not Supplemented with Vitamin D | en |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.relation.publisherversion | https://doi.org/10.3390/ijms231911846 | es |
dc.identifier.doi | 10.3390/ijms231911846 | |
dc.relation.projectID | info:eu-repo/grantAgreement/UVA//SO-1-2020/ES/ | es |
dc.identifier.essn | 1422-0067 | |
dc.journal.title | International Journal of Molecular Sciences | en |
dc.volume.number | 23 | es |
dc.issue.number | 19 | es |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |