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dc.contributor.authorCavia Saiz, Mónica 
dc.contributor.authorArnaez, Juan
dc.contributor.authorCilla, Amaia
dc.contributor.authorPuente, Laura
dc.contributor.authorGarcía-Miralles, Laura C.
dc.contributor.authorMuñiz Rodríguez, Pilar 
dc.date.accessioned2023-11-17T13:20:22Z
dc.date.available2023-11-17T13:20:22Z
dc.date.issued2023-06
dc.identifier.urihttp://hdl.handle.net/10259/8051
dc.description.abstractThe clinical relevance of stress biomarkers in newborns is well established. Currently, oxidative stress (OS) parameters are seen to play an important role in neonatal resuscitation guidelines, and a link has been observed between the amount of oxygen delivered and the level of OS and the development of various pathologies. The aim of the current study was to investigate changes in neonatal plasma and urine OS status during the first hours after birth. A lower antioxidant capacity (TAC) and higher levels of malondialdehyde in blood were observed in newborns at the time of birth compared with results 48 h postnatally. The urine revealed a significant and progressive increase in TAC and creatinine during the first 36 h of life, with a progressive decline thereafter. Meanwhile, malondialdehyde in urine samples showed no significant differences over time. Overall, the correlation between blood and urine parameters was poor, except for the relationship between umbilical vein glutathione reduced/oxidized ratio and urine malondialdehyde (r = 0.7; p = 0.004) and between TAC in the umbilical artery and urine (r = −0.547; p = 0.013). The biomarkers evaluated in this study could be established as reference values for neonatal OS.en
dc.description.sponsorshipThis research was funded by Fundación Burgos por la Investigación de la Salud (grant number 1088) and Gerencia Regional de Castilla y Leon (grant number GRS 1773/A/18).en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofAntioxidants. 2023, V. 12, n. 6, 1249es
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectOxidative stressen
dc.subjectInfanten
dc.subjectBirthen
dc.subjectCord blooden
dc.subjectGlutathioneen
dc.subjectMalondialdehydeen
dc.subjectCarbonylen
dc.subjectCreatinineen
dc.subject.otherAlimentoses
dc.subject.otherFooden
dc.subject.otherBiología moleculares
dc.subject.otherMolecular biologyen
dc.subject.otherBioquímicaes
dc.subject.otherBiochemistryen
dc.titleBiomarkers of Oxidative Stress in Healthy Infants within the First Three Days after Birthen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.3390/antiox12061249es
dc.identifier.doi10.3390/antiox12061249
dc.identifier.essn2076-3921
dc.journal.titleAntioxidantsen
dc.volume.number12es
dc.issue.number6es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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