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dc.contributor.authorGerardi, Gisela 
dc.contributor.authorCavia Saiz, Mónica 
dc.contributor.authorRivero Pérez, Maria Dolores 
dc.contributor.authorGonzález San José, Mª Luisa 
dc.contributor.authorMuñiz Rodríguez, Pilar 
dc.date.accessioned2023-11-17T13:53:11Z
dc.date.available2023-11-17T13:53:11Z
dc.date.issued2019-07
dc.identifier.issn1756-4646
dc.identifier.issn1756-4646
dc.identifier.urihttp://hdl.handle.net/10259/8054
dc.description.abstractWine by-products show great potential as source of bioactive compounds that protect the vascular endothelial function by the modulation of both Nrf2 and Nf-κB pathways. This study investigates the pathways involved in the effects of a red wine pomace product (rWPP) against inflammatory and oxidative damage in hyperglycemic EA.hy926 endothelial cells. rWPP-digested fractions showed an inhibitory effect on IKK/IκBα/NF-κB pathway and a stimulatory effect on Akt-p38-MAPK/Nrf2 pathway with an impact on their antioxidant and anti-inflammatory downstream targets. In addition, the pathways regulation was also accompanied by downregulation of the gene expression of superoxide dismutase 2, cyclooxygenase 2 and NADPH oxidase 4. These results suggest the expression of SOD2 as an early adaptive response to the inflammatory effect mediated by NF-κB in hyperglycemic cells, and the treatment with the rWPP-digested fractions regulate this inflammatory process by Nrf2 pathway increased expression of antioxidant enzymes.en
dc.description.sponsorshipThe authors thank the financial support of the Autonomous Government of Castilla y León (Research project BU282U13).en
dc.format.mimetypeapplication/pdf
dc.language.isospaes
dc.publisherElsevieres
dc.relation.ispartofJournal of Functional Foods. 2019, V. 58, p. 255-265en
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPolyphenolsen
dc.subjectWine pomaceen
dc.subjectEndothelial dysfunctionen
dc.subjectNF-κBen
dc.subjectNrf2en
dc.subjectp38MAPKen
dc.subjectAkten
dc.subjectSIRT1en
dc.subjectOxidative stressen
dc.subjectEA.hy926en
dc.subjectPhase 2 enzymesen
dc.subjectSOD2en
dc.subjectNOX4en
dc.subjectCOX2en
dc.subject.otherAlimentoses
dc.subject.otherFooden
dc.subject.otherBioquímicaes
dc.subject.otherBiochemistryen
dc.subject.otherBiología moleculares
dc.subject.otherMolecular biologyen
dc.titleModulation of Akt-p38-MAPK/Nrf2/SIRT1 and NF-κB pathways by wine pomace product in hyperglycemic endothelial cell lineen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1016/j.jff.2019.05.003es
dc.identifier.doi10.1016/j.jff.2019.05.003
dc.relation.projectIDinfo:eu-repo/grantAgreement/Junta de Castilla y León//BU282U13//APROVECHAMIENTO DE RESIDUOS DE VINIFICACIÓN: ESTUDIO DE SU EXPLOTACIÓN COMO INGREDIENTE FUNCIONAL Y ANÁLISIS DE LAS POSIBLES ALEGACIONES SALUDABLES/es
dc.journal.titleJournal of Functional Foodses
dc.volume.number58es
dc.page.initial255es
dc.page.final265es
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones


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