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dc.contributor.authorCaño Espinel, Manuela del
dc.contributor.authorAcebes, Judith R.
dc.contributor.authorSánchez, Diego
dc.contributor.authorGanfornina, María D.
dc.date.accessioned2023-12-14T15:44:53Z
dc.date.available2023-12-14T15:44:53Z
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/10259/8207
dc.description.abstractA diverse set of neurodegenerative disorders are caused by abnormal extensions of polyglutamine (poly-Q) stretches in various, functionally unrelated proteins. A common feature of these diseases is altered proteostasis. Autophagy induction is part of the endogenous response to poly-Q protein expression. However, if autophagy is not resolved properly, clearance of toxic proteins or aggregates cannot occur effectively. Likewise, excessive autophagy induction can cause autophagic stress and neurodegeneration. The Lipocalins ApoD, Glial Lazarillo (GLaz) and Neural Lazarillo (NLaz) are neuroprotectors upon oxidative stress or aging. In this work we test whether these Lipocalins also protect against poly-Q-triggered deterioration of protein quality control systems.en
dc.description.sponsorshipThis work was supported by grants to MDG and DS: Junta de Castilla y León (JCyL) grant VA180A11-2, and Ministerio de Ciencia e Innovación (MICINN) grants BFU2008-01170 and BFU2011-23978. MdC-E was supported by a University of Valladolid, predoctoral fellowship.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherBMCes
dc.relation.ispartofMolecular Neurodegeneration. 2015, V. 10, n. 11, p. 1-18es
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAutophagyen
dc.subjectNeurodegenerationen
dc.subjectNeuroprotectionen
dc.subjectPolyubiquitinated protein clearanceen
dc.subjectDrosophilaen
dc.subjectGLazes
dc.subjectNLazes
dc.subjectApoDes
dc.subjectGstS1es
dc.subjectAtg1/ULK1es
dc.subjectAtg4aes
dc.subjectAtg8a/LC3es
dc.subjectp62es
dc.subject.otherNeurologíaes
dc.subject.otherNeurologyen
dc.subject.otherMedicinaes
dc.subject.otherMedicineen
dc.titleLazarillo-related Lipocalins confer long-term protection against type I Spinocerebellar Ataxia degeneration contributing to optimize selective autophagyen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1186/s13024-015-0009-8es
dc.identifier.doi10.1186/s13024-015-0009-8
dc.identifier.essn1750-1326
dc.journal.titleMolecular Neurodegenerationes
dc.volume.number10es
dc.issue.number11es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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