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dc.contributor.authorBirnir, Bjorn
dc.contributor.authorCarpio, Ana
dc.contributor.authorCebrián de Barrio, Elena 
dc.contributor.authorVidal, Perfecto
dc.date.accessioned2024-01-09T12:56:13Z
dc.date.available2024-01-09T12:56:13Z
dc.date.issued2018
dc.identifier.issn1007-5704
dc.identifier.urihttp://hdl.handle.net/10259/8269
dc.description.abstractQuantifying the action of antibiotics on biofilms is essential to devise therapies against chronic infections. Biofilms are bacterial communities attached to moist surfaces, sheltered from external aggressions by a polymeric matrix. Coupling a dynamic energy budget based description of cell metabolism to surrounding concentration fields, we are able to approximate survival curves measured for different antibiotics. We reproduce numerically stratified distributions of cell types within the biofilm and introduce ways to incorporate different resistance mechanisms. Qualitative predictions follow that are in agreement with experimental observations, such as higher survival rates of cells close to the substratum when employing antibiotics targeting active cells or enhanced polymer production when antibiotics are administered. The current computational model enables validation and hypothesis testing when developing therapies.en
dc.description.sponsorshipResearch partially supported by the NILS Mobility Program grant No. 001-ABELIM-2013 through the EEA financial mechanism and MINECO grant No. MTM2014-56948-C2-1-P.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherElsevieres
dc.relation.ispartofCommunications in Nonlinear Science and Numerical Simulation. 2018, V. 54, p. 70-83es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDynamic energy budgeten
dc.subjectBacterial biofilmen
dc.subjectAntibioticen
dc.subjectNumerical simulationen
dc.subject.otherMicrobiologíaes
dc.subject.otherMicrobiologyen
dc.subject.otherMatemáticases
dc.subject.otherMathematicsen
dc.titleDynamic energy budget approach to evaluate antibiotic effects on biofilmsen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1016/j.cnsns.2017.05.016es
dc.identifier.doi10.1016/j.cnsns.2017.05.016
dc.identifier.essn1878-7274
dc.journal.titleCommunications in Nonlinear Science and Numerical Simulationen
dc.volume.number54es
dc.page.initial70es
dc.page.final83es
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersiones


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