dc.contributor.author | Alonso Carrillo, Daniel | |
dc.contributor.author | Carreira Barral, Israel | |
dc.contributor.author | Mielczarek, Marcin | |
dc.contributor.author | Sancho Medina, Andrea | |
dc.contributor.author | Herran, Enara | |
dc.contributor.author | Vairo, Claudia | |
dc.contributor.author | Pozo, Ángel del | |
dc.contributor.author | Luzuriaga, Iris | |
dc.contributor.author | Lazcanoiturburu, Nerea | |
dc.contributor.author | Ibarrola, Oihane | |
dc.contributor.author | Ponce, Sara | |
dc.contributor.author | Villar Vidal, María | |
dc.contributor.author | García Valverde, María | |
dc.contributor.author | Quesada Pato, Roberto | |
dc.date.accessioned | 2024-02-07T08:07:42Z | |
dc.date.available | 2024-02-07T08:07:42Z | |
dc.date.issued | 2023-08 | |
dc.identifier.issn | 1477-0520 | |
dc.identifier.uri | http://hdl.handle.net/10259/8609 | |
dc.description.abstract | Six novel click-tambjamines (1–6) bearing an alkyl chain of varying length linked to the imine moiety have been formulated in nanostructured lipid carriers (NLCs) to evaluate their transmembrane anion transport activity both when free (i.e., not encapsulated) and nanoformulated. Nanostructured lipid carriers (NLCs) are an example of drug delivery systems (DDSs) that stand out because of their versatility. In this work we show that NLCs can be used to efficiently formulate highly lipophilic anionophores and experiments conducted in model liposomes reveal that these formulations are adequate to deliver anionophores without compromising their transport activity. This result paves the way to facilitate the study of highly lipophilic anionophores and their potential use as future drugs. | en |
dc.description.sponsorship | This research has been financially supported by Consejería de Educación de la Junta de Castilla y León and European Regional Development Fund (ERDF) (project BU067P20), Ministerio de Ciencia e Innovación (project PID2020-117610RB-I00), Gobierno Vasco (Elkartek program 2021 KK-2021/00052), and Alava Innova program 2021 (INNOAS-2021/00003) of the Provincial Council of Alava. D. A.-C. and I. C.-B. thank Consejería de Educación de la Junta de Castilla y León, ERDF and European Social Fund (ESF) for their pre-doctoral and post-doctoral contracts, respectively. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | es |
dc.publisher | Royal Society of Chemistry | en |
dc.relation.ispartof | Organic & Biomolecular Chemistry. 2023, V. 21, n. 38, p. 7753-7757 | en |
dc.rights | Attribution-NonCommercial 3.0 Unported | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/ | * |
dc.subject.other | Química orgánica | es |
dc.subject.other | Chemistry, Organic | en |
dc.subject.other | Bioquímica | es |
dc.subject.other | Biochemistry | en |
dc.title | Formulation and evaluation of anion transporters in nanostructured lipid carriers | en |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.relation.publisherversion | https://doi.org/10.1039/D3OB01182H | es |
dc.identifier.doi | 10.1039/D3OB01182H | |
dc.identifier.essn | 1477-0539 | |
dc.journal.title | Organic & Biomolecular Chemistry | en |
dc.volume.number | 21 | es |
dc.issue.number | 38 | es |
dc.page.initial | 7753 | es |
dc.page.final | 7757 | es |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |
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