Afficher la notice abrégée

dc.contributor.authorAyala, Alba
dc.contributor.authorTriviño Juárez, José Matías
dc.contributor.authorForjaz, María Joao
dc.contributor.authorRodríguez Blázquez, Carmen
dc.contributor.authorRojo Abuin, José Manuel
dc.contributor.authorMartínez Martín, Pablo
dc.contributor.authorCubo Delgado, Esther 
dc.contributor.authorELEP Group
dc.date.accessioned2024-03-08T08:57:26Z
dc.date.available2024-03-08T08:57:26Z
dc.date.issued2017-10
dc.identifier.urihttp://hdl.handle.net/10259/8780
dc.description.abstractObjective: The aim of this study is to present a predictive model of Parkinson’s disease (PD) global severity, measured with the Clinical Impression of Severity Index for Parkinson’s Disease (CISI-PD). Methods: This is an observational, longitudinal study with annual follow-up assessments over 3 years (four time points). A multilevel analysis and multiple imputation techniques were performed to generate a predictive model that estimates changes in the CISI-PD at 1, 2, and 3 years. Results: The clinical state of patients (CISI-PD) significantly worsened in the 3-year follow-up. However, this change was of small magnitude (effect size: 0.44). The following baseline variables were significant predictors of the global severity change: baseline global severity of disease, levodopa equivalent dose, depression and anxiety symptoms, autonomic dysfunction, and cognitive state. The goodness-of-fit of the model was adequate, and the sensitive analysis showed that the data imputation method applied was suitable. Conclusion: Disease progression depends more on the individual’s baseline characteristics than on the 3-year time period. Results may contribute to a better understanding of the evolution of PD including the non-motor manifestations of the disease.en
dc.description.sponsorshipThe Spanish Longitudinal PD Patient Study (Estudio longitudinal de pacientes con enfermedad de Parkinson) was supported by an Intramural Research Programme grant from the Carlos III Institute of Health (Code: EPY1271/05). Partial funding was also obtained from the following grants: ENVACES (MINECO/FEDER/UE, ref. CSO2015-64115-R) and ENCAGE-CM (Comunidad de Madrid, ref. S2015/HUM-3367).en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherFrontiers Mediaen
dc.relation.ispartofFrontiers in Neurology. 2017, V. 8en
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectParkinson’s diseaseen
dc.subjectDisease global severityen
dc.subjectPredictive modelen
dc.subjectMultilevel analysisen
dc.subjectMultiple imputationen
dc.subject.otherSistema nervioso-Enfermedadeses
dc.subject.otherNervous system-Diseasesen
dc.subject.otherNeurologíaes
dc.subject.otherNeurologyen
dc.subject.otherMedicinaes
dc.subject.otherMedicineen
dc.titleParkinson’s Disease Severity at 3 Years Can Be Predicted from Non-Motor Symptoms at Baselineen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.3389/fneur.2017.00551es
dc.identifier.doi10.3389/fneur.2017.00551
dc.identifier.essn1664-2295
dc.journal.titleFrontiers in Neurologyen
dc.volume.number8es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


Fichier(s) constituant ce document

Thumbnail

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée