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dc.contributor.authorCubo Delgado, Esther 
dc.contributor.authorGallego Nieto, César
dc.contributor.authorElizari Roncal, Miren
dc.contributor.authorBarroso Pérez, Mª Teresa
dc.contributor.authorCollazo Riobó, Carla 
dc.contributor.authorDelgado López, Pedro David
dc.date.accessioned2024-03-08T12:47:10Z
dc.date.available2024-03-08T12:47:10Z
dc.date.issued2019-07
dc.identifier.urihttp://hdl.handle.net/10259/8787
dc.descriptionArtículo de revisiónes
dc.description.abstractBackground: Restless legs syndrome (RLS) is a common sleep disorder,. although controversial, growing evidence relates the presence of RLS to an increased risk of mortality, mainly due to cardiovascular events. The aim of this article was to review the role of RLS as a risk factor of mortality according to independent cohort studies. Methods: We performed a literature review via PubMed database for articles relating RLS and mortality. We used the random-effects model to calculate the pooled effect estimates on mortality. Heterogeneity between studies was assessed using quantitative and qualitative analysis. Results: Out of 100 articles identified, 13 were finally included. Although studies were heterogeneous (p = 0.001), no significant publication bias was found. When all cohort studies were considered, the random-effects model yielded a significantly increased risk of mortality in RLS versus non-RLS patients (13 studies, hazard ratio [HR] = 1.52, 95% confidence interval [CI] 1.28–1.80). However, this association was not statistically significant when only cohort studies using the international RLS diagnostic criteria were considered (5 studies, HR = 1.63, 95% CI 0.94–2.81). Discussion: The results of this meta-analysis suggest that RLS seems to be a risk factor of mortality, although this association is conditioned by the diagnostic criteria used in the studies. Future long-term follow-up standardized mortality studies are needed to address this important question that carries potential impact on population global health.en
dc.description.sponsorshipThis work was supported by a grant from the Castilla y Leon Health Department (GRS 1764/A/18).en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherUbiquity Pressen
dc.relation.ispartofTremor and Other Hyperkinetic Movements. 2019, V. 9en
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Unported*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/*
dc.subjectRestless legs syndromeen
dc.subjectMortalityen
dc.subjectSurvivalen
dc.subjectEpidemiologyen
dc.subjectCohortsen
dc.subjectSleep disorderen
dc.subject.otherSistema nervioso-Enfermedadeses
dc.subject.otherNervous system-Diseasesen
dc.subject.otherNeurologíaes
dc.subject.otherNeurologyen
dc.subject.otherMedicinaes
dc.subject.otherMedicineen
dc.titleIs Restless Legs Syndrome Associated with an Increased Risk of Mortality? A Meta-Analysis of Cohort Studiesen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://tremorjournal.org/articles/10.5334/tohm.508es
dc.identifier.doi10.5334/tohm.508
dc.identifier.essn2160-8288
dc.journal.titleTremor and Other Hyperkinetic Movementsen
dc.volume.number9es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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