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dc.contributor.authorSantos García, Diego
dc.contributor.authorDeus-Fonticoba, Teresa de
dc.contributor.authorGonzález, José Manuel Paz
dc.contributor.authorBartolomé, Carlos Cores
dc.contributor.authorValdés Aymerich, Lorena
dc.contributor.authorEnríquez Muñoz, J. G.
dc.contributor.authorSuárez, Esther
dc.contributor.authorJesús, Silvia
dc.contributor.authorAguilar, Miquel
dc.contributor.authorPastor, Pau
dc.contributor.authorPlanellás, Lluis L.
dc.contributor.authorCosgaya, Marina
dc.contributor.authorGarcía Caldentey, Juan
dc.contributor.authorCaballol, Núria
dc.contributor.authorLegarda, Inés
dc.contributor.authorHernández Vara, Jorge
dc.contributor.authorCabo López, Iria
dc.contributor.authorLópez Manzanares, Lydia
dc.contributor.authorGonzález Aramburu, Isabel
dc.contributor.authorÁvila Rivera, María A.
dc.contributor.authorCatalán, María José
dc.contributor.authorNogueira, Víctor
dc.contributor.authorPuente, Víctor
dc.contributor.authorGarcía Moreno, José Manuel
dc.contributor.authorBorrue, Carmen
dc.contributor.authorSolano Vila, Berta
dc.contributor.authorÁlvarez Saúco, María
dc.contributor.authorVela Desojo, Lydia
dc.contributor.authorEscalante Arroyo, Sonia
dc.contributor.authorCubo Delgado, Esther 
dc.contributor.authorCarrillo Padilla, Francisco
dc.contributor.authorMartínez Castrillo, Juan Carlos
dc.contributor.authorSánchez Alonso, Pilar
dc.contributor.authorAlonso Losada, María Gema
dc.contributor.authorLópez Ariztegui, Nuria
dc.contributor.authorGastón, Itziar
dc.contributor.authorKulisevsky Bojarsky, Jaume
dc.contributor.authorBlázquez Estrada, Marta
dc.contributor.authorSeijo, Manuel
dc.contributor.authorRuíz Martínez, Javier
dc.contributor.authorValero, Caridad
dc.contributor.authorKurtis, Mónica M.
dc.contributor.authorFabregues, Oriol de
dc.contributor.authorGonzález Ardura, Jessica
dc.contributor.authorOrdás Bandera, Carlos Manuel
dc.contributor.authorLópez Díaz, Luis M.
dc.contributor.authorMir, Pablo
dc.contributor.authorMartínez Martín, Pablo
dc.contributor.authorCOPPADIS Study Group
dc.date.accessioned2024-03-11T12:42:39Z
dc.date.available2024-03-11T12:42:39Z
dc.date.issued2021-05
dc.identifier.issn2090-8083
dc.identifier.urihttp://hdl.handle.net/10259/8800
dc.description.abstractIntroduction. In a degenerative disorder such as Parkinson’s disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr’s motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient’s quality of life (QoL) with regard to a defined clinical stage. Materials and Methods. Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS = 0–20; B: NMSS = 21–40; C: NMSS = 41–70; D: NMSS ≥ 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results. A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (; e.g., PDQ-39SI in 1D [n = 15] vs 2A [n = 101]: 28.6 ± 17.1 vs 7.9 ± 5.8; ). Conclusion. The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the H&Y. Patients with a lower H&Y stage may be more affected if they have a greater NMS burden.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherHindawien
dc.relation.ispartofParkinson's Disease. 2021, V. 2021, p. 1-16en
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.otherSistema nervioso-Enfermedadeses
dc.subject.otherNervous system-Diseasesen
dc.subject.otherMedicinaes
dc.subject.otherMedicineen
dc.titleStaging Parkinson’s Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Lifeen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1155/2021/8871549es
dc.identifier.doi10.1155/2021/8871549
dc.identifier.essn2042-0080
dc.journal.titleParkinson's Diseaseen
dc.volume.number2021es
dc.page.initial1es
dc.page.final16es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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