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dc.contributor.authorSantos García, Diego
dc.contributor.authorDeus-Fonticoba, Teresa de
dc.contributor.authorCores Bartolomé, Carlos
dc.contributor.authorNaya Ríos, Lucía
dc.contributor.authorGarcía Roca, Lucía
dc.contributor.authorMartínez Miró, Cristina
dc.contributor.authorCanfield, Héctor
dc.contributor.authorJesús, Silvia
dc.contributor.authorAguilar, Miquel
dc.contributor.authorPastor, Pau
dc.contributor.authorCosgaya, Marina
dc.contributor.authorGarcía Caldentey, Juan
dc.contributor.authorCaballol, Núria
dc.contributor.authorLegarda, Inés
dc.contributor.authorHernández Vara, Jorge
dc.contributor.authorCabo López, Iria
dc.contributor.authorLópez Manzanares, Lydia
dc.contributor.authorGonzález Aramburu, Isabel
dc.contributor.authorÁvila Rivera, María A.
dc.contributor.authorGómez Mayordomo, Víctor
dc.contributor.authorNogueira, Víctor
dc.contributor.authorPuente, Víctor
dc.contributor.authorDotor, Julio
dc.contributor.authorBorrue, Carmen
dc.contributor.authorSolano Vila, Berta
dc.contributor.authorÁlvarez Saúco, María
dc.contributor.authorVela Desojo, Lydia
dc.contributor.authorEscalante Arroyo, Sonia
dc.contributor.authorCubo Delgado, Esther 
dc.contributor.authorCarrillo Padilla, Francisco
dc.contributor.authorMartínez Castrillo, Juan Carlos
dc.contributor.authorSánchez Alonso, Pilar
dc.contributor.authorAlonso Losada, María Gema
dc.contributor.authorLópez Ariztegui, Nuria
dc.contributor.authorGastón, Itziar
dc.contributor.authorKulisevsky Bojarsky, Jaume
dc.contributor.authorBlázquez Estrada, Marta
dc.contributor.authorSeijo, Manuel
dc.contributor.authorRuíz Martínez, Javier
dc.contributor.authorValero, Caridad
dc.contributor.authorKurtis, Mónica M.
dc.contributor.authorFabregues, Oriol de
dc.contributor.authorGonzález Ardura, Jessica
dc.contributor.authorAlonso Redondo, Rubén
dc.contributor.authorOrdás Bandera, Carlos Manuel
dc.contributor.authorLópez Díaz, Luis M.
dc.contributor.authorMcAfee, Darrian
dc.contributor.authorMartínez Martín, Pablo
dc.contributor.authorMir, Pablo
dc.contributor.authorCOPPADIS Study Group
dc.date.accessioned2024-03-12T10:25:47Z
dc.date.available2024-03-12T10:25:47Z
dc.date.issued2021-09
dc.identifier.urihttp://hdl.handle.net/10259/8804
dc.description.abstractBackground and objective: The aim of this study was to compare the progression of independence in activities of daily living (ADL) in Parkinson’s disease (PD) patients versus a control group, as well as to identify predictors of disability progression and functional dependency (FD). Patients and Methods: PD patients and control subjects, who were recruited from 35 centers of Spain from the COPPADIS cohort between January 2016 and November 2017 (V0), were included. Patients and subjects were then evaluated again at the 2-year follow-up (V2). Disability was assessed with the Schwab & England Activities of Daily Living Scale (S&E-ADLS) at V0 and V2. FD was defined as an S&E-ADLS score less than 80%. Results: In the PD group, a significant decrease in the S&E-ADLS score from V0 to V2 (N = 507; from 88.58 ± 10.19 to 84.26 ± 13.38; p < 0.0001; Cohen’s effect size = −0.519) was observed but not in controls (N = 124; from 98.87 ± 6.52 to 99.52 ± 2.15; p = 0.238). When only patients considered functional independent at baseline were included, 55 out of 463 (11.9%) converted to functional dependent at V2. To be a female (OR = 2.908; p = 0.009), have longer disease duration (OR = 1.152; p = 0.002), have a non-tremoric motor phenotype at baseline (OR = 3.574; p = 0.004), have a higher score at baseline in FOGQ (OR = 1.244; p < 0.0001) and BDI-II (OR = 1.080; p = 0.008), have a lower score at baseline in PD-CRS (OR = 0.963; p = 0.008), and have a greater increase in the score from V0 to V2 in UPDRS-IV (OR = 1.168; p = 0.0.29), FOGQ (OR = 1.348; p < 0.0001) and VAFS-Mental (OR = 1.177; p = 0.013) (adjusted R-squared 0.52; Hosmer and Lemeshow test = 0.94) were all found to be independent predictors of FD at V2. Conclusions: In conclusion, autonomy for ADL worsens in PD patients compared to controls. Cognitive impairment, gait problems, fatigue, depressive symptoms, more advanced disease, and a non-tremor phenotype are independent predictors of FD in the short-term.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherMDPIen
dc.relation.ispartofDiagnostics. 2021, V. 11, n. 10, 1801en
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectActivities of Daily Livingen
dc.subjectDependencyen
dc.subjectDisabilityen
dc.subjectGaiten
dc.subjectParkinson’s diseaseen
dc.subject.otherSistema nervioso-Enfermedadeses
dc.subject.otherNervous system-Diseasesen
dc.subject.otherMedicinaes
dc.subject.otherMedicineen
dc.subject.otherNeurologíaes
dc.subject.otherNeurologyen
dc.titlePredictors of Loss of Functional Independence in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up and Comparison with a Control Groupen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.3390/diagnostics11101801es
dc.identifier.doi10.3390/diagnostics11101801
dc.identifier.essn2075-4418
dc.journal.titleDiagnosticsen
dc.volume.number11es
dc.issue.number10es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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