Mostra i principali dati dell'item

dc.contributor.authorSantos García, Diego
dc.contributor.authorDeus-Fonticoba, Teresa de
dc.contributor.authorCores Bartolomé, Carlos
dc.contributor.authorCanfield, Héctor
dc.contributor.authorPaz González, José Manuel
dc.contributor.authorMartínez Miró, Cristina
dc.contributor.authorValdés Aymerich, Lorena
dc.contributor.authorSuárez Castro, Ester
dc.contributor.authorJesús, Silvia
dc.contributor.authorAguilar, Miquel
dc.contributor.authorPastor, Pau
dc.contributor.authorPlanellás, Lluis L.
dc.contributor.authorCosgaya, Marina
dc.contributor.authorGarcía Caldentey, Juan
dc.contributor.authorCaballol, Núria
dc.contributor.authorLegarda, Inés
dc.contributor.authorHernández Vara, Jorge
dc.contributor.authorCabo López, Iria
dc.contributor.authorLópez Manzanares, Lydia
dc.contributor.authorGonzález Aramburu, Isabel
dc.contributor.authorÁvila Rivera, María A.
dc.contributor.authorCatalán, María José
dc.contributor.authorNogueira, Víctor
dc.contributor.authorPuente, Víctor
dc.contributor.authorDotor, Julio
dc.contributor.authorBorrue, Carmen
dc.contributor.authorSolano, Berta
dc.contributor.authorÁlvarez Saúco, María
dc.contributor.authorVela Desojo, Lydia
dc.contributor.authorEscalante Arroyo, Sonia
dc.contributor.authorCubo Delgado, Esther 
dc.contributor.authorCarrillo Padilla, Francisco
dc.contributor.authorMartínez Castrillo, Juan Carlos
dc.contributor.authorSánchez Alonso, Pilar
dc.contributor.authorAlonso Losada, María Gema
dc.contributor.authorLópez Ariztegui, Nuria
dc.contributor.authorGastón, Itziar
dc.contributor.authorKulisevsky Bojarsky, Jaume
dc.contributor.authorBlázquez Estrada, Marta
dc.contributor.authorSeijo, Manuel
dc.contributor.authorRuíz Martínez, Javier
dc.contributor.authorValero, Caridad
dc.contributor.authorKurtis, Mónica M.
dc.contributor.authorFabregues, Oriol de
dc.contributor.authorGonzález Ardura, Jessica
dc.contributor.authorAlonso Redondo, Rubén
dc.contributor.authorOrdás Bandera, Carlos Manuel
dc.contributor.authorLópez Díaz, Luis M.
dc.contributor.authorMcAfee, Darrian
dc.contributor.authorMartínez Martín, Pablo
dc.contributor.authorMir, Pablo
dc.contributor.authorCOPPADIS Study Group
dc.date.accessioned2024-03-12T10:53:35Z
dc.date.available2024-03-12T10:53:35Z
dc.date.issued2021-06
dc.identifier.urihttp://hdl.handle.net/10259/8805
dc.description.abstractBackground and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson’s disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months ± 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 ± 37.62 to 53.55 ± 42.28; p < 0.0001; N = 501; 60.2% males, mean age 62.59 ± 8.91) compared to no change observed in controls (from 14.74 ± 18.72 to 14.65 ± 21.82; p = 0.428; N = 122; 49.5% males, mean age 60.99 ± 8.32) (p < 0.0001). NMSS total score at baseline (β = −0.52), change from V0 to V2 in PDSS (Parkinson’s Disease Sleep Scale) (β = −0.34), and change from V0 to V2 in NPI (Neuropsychiatric Inventory) (β = 0.25) provided the highest contributions to the model (adjusted R-squared 0.41; Durbin-Watson test = 1.865). Conclusions: Global NMS burden demonstrates short-term progression in PD patients but not in controls and identifies worsening sleep problems and neuropsychiatric symptoms as significant independent predictors of this NMS progression.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherMDPIen
dc.relation.ispartofJournal of Personalized Medicine. 2021, V. 11, n. 7, 626en
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMooden
dc.subjectNon-motor symptomsen
dc.subjectParkinson’s diseaseen
dc.subjectProgressionen
dc.subjectQuality of lifeen
dc.subject.otherSistema nervioso-Enfermedadeses
dc.subject.otherNervous system-Diseasesen
dc.subject.otherMedicinaes
dc.subject.otherMedicineen
dc.subject.otherNeurologíaes
dc.subject.otherNeurologyen
dc.titlePredictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Upen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.3390/jpm11070626es
dc.identifier.doi10.3390/jpm11070626
dc.identifier.essn2075-4426
dc.journal.titleJournal of Personalized Medicineen
dc.volume.number11es
dc.issue.number7es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


Files in questo item

Thumbnail

Questo item appare nelle seguenti collezioni

Mostra i principali dati dell'item