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dc.contributor.authorMartínez-Horta, Saul
dc.contributor.authorBerj-Kasem, Helena
dc.contributor.authorHorta-Barba, Andrea
dc.contributor.authorPascual Sedano, Berta
dc.contributor.authorSantos García, Diego
dc.contributor.authorDeus-Fonticoba, Teresa de
dc.contributor.authorJesús, Silvia
dc.contributor.authorAguilar, Miquel
dc.contributor.authorPlanellás, Lluis L.
dc.contributor.authorGarcía Caldentey, Juan
dc.contributor.authorCaballol, Núria
dc.contributor.authorVives Pastor, Bárbara
dc.contributor.authorHernández Vara, Jorge
dc.contributor.authorCabo López, Iria
dc.contributor.authorLópez Manzanares, Lydia
dc.contributor.authorGonzález Aramburu, Isabel
dc.contributor.authorÁvila Rivera, María A.
dc.contributor.authorCatalán, María José
dc.contributor.authorLópez Díaz, Luis M.
dc.contributor.authorPuente, Víctor
dc.contributor.authorGarcía Moreno, José Manuel
dc.contributor.authorBorrue, Carmen
dc.contributor.authorSolano Vila, Berta
dc.contributor.authorÁlvarez Saúco, María
dc.contributor.authorVela Desojo, Lydia
dc.contributor.authorEscalante Arroyo, Sonia
dc.contributor.authorCubo Delgado, Esther 
dc.contributor.authorCarrillo Padilla, Francisco
dc.contributor.authorMartínez Castrillo, Juan Carlos
dc.contributor.authorSánchez Alonso, Pilar
dc.contributor.authorAlonso Losada, María Gema
dc.contributor.authorLópez Ariztegui, Nuria
dc.contributor.authorGastón, Itziar
dc.contributor.authorBlázquez Estrada, Marta
dc.contributor.authorSeijo, Manuel
dc.contributor.authorRuíz Martínez, Javier
dc.contributor.authorValero, Caridad
dc.contributor.authorKurtis, Mónica M.
dc.contributor.authorFabregues, Oriol de
dc.contributor.authorGonzález Ardura, Jessica
dc.contributor.authorPrieto Jurczynska, Cristina
dc.contributor.authorMartínez Martín, Pablo
dc.contributor.authorMir, Pablo
dc.contributor.authorKulisevsky Bojarsky, Jaume
dc.contributor.authorCOPPADIS Study Group
dc.date.accessioned2024-03-12T12:19:24Z
dc.date.available2024-03-12T12:19:24Z
dc.date.issued2021-12
dc.identifier.urihttp://hdl.handle.net/10259/8809
dc.description.abstractBackground: Identifying modifable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods: Using a standard approach for the assessment of global cognition in PD and controlling for the efects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, meta‑ bolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results: Among the overall sample, 21% of participants were classifed as PD-MCI (n=114) and 4% as PDD (n=26). The prevalence of hypertension, diabetes and dyslipidemia was signifcantly higher in cognitively impaired patients while no between-group diferences were found for smoking, alcohol intake or use of supplementary vitamins. Bet‑ ter cognitive scores were signifcantly associated with regular physical exercise (p<0.05) and cognitive stimulation (<0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p<0.05), Il6 (p<0.05), iron (p<0.05), and homocysteine (p<0.005) levels, and positively associated with vitamin B12 levels (p<0.005). Conclusions: We extend previous fndings regarding the positive and negative infuence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentiallyen
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherSpringer Natureen
dc.relation.ispartofBMC Neurology. 2021, V. 21, n. 1en
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectParkinson’s diseaseen
dc.subjectPD-MCIen
dc.subjectCognitionen
dc.subjectLifestyleen
dc.subjectCoppadisen
dc.subject.otherSistema nervioso-Enfermedadeses
dc.subject.otherNervous system-Diseasesen
dc.subject.otherMedicinaes
dc.subject.otherMedicineen
dc.subject.otherNeurologíaes
dc.subject.otherNeurologyen
dc.titleIdentifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s diseaseen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1186/s12883-021-02485-1es
dc.identifier.doi10.1186/s12883-021-02485-1
dc.identifier.essn1471-2377
dc.journal.titleBMC Neurologyen
dc.volume.number21es
dc.issue.number1es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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