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dc.contributor.authorKovács, Norbert
dc.contributor.authorBergmann, Lars
dc.contributor.authorAnca-Herschkovitsch, Marieta
dc.contributor.authorCubo Delgado, Esther 
dc.contributor.authorDavis, Thomas L.
dc.contributor.authorIansek, Robert
dc.contributor.authorSiddiqui, Mustafa S.
dc.contributor.authorSimu, Mihaela
dc.contributor.authorStandaert, David G.
dc.contributor.authorChaudhuri, K. Ray
dc.contributor.authorBourgeois, Paul
dc.contributor.authorGao, Tianming
dc.contributor.authorKukreja, Pavnit
dc.contributor.authorPontieri, Francesco E.
dc.contributor.authorAldred, Jason
dc.date.accessioned2024-03-14T11:01:55Z
dc.date.available2024-03-14T11:01:55Z
dc.date.issued2022-04
dc.identifier.issn1877-7171
dc.identifier.urihttp://hdl.handle.net/10259/8820
dc.description.abstractBackground: It is believed that motor symptoms, including dyskinesia, and non-motor symptoms impact health-related quality of life (HRQoL) in patients with Parkinson’s disease (PD), and that improvements in these metrics are correlated. Objective: Investigate the relationship between HRQoL and measures of PD severity and treatment efficacy, including motor and non-motor symptoms. Methods: This was a planned investigation of an international, prospective, single-arm, post-marketing observational study of the long-term effectiveness of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced PD. Pearson correlation coefficients (PCC) were calculated for baseline and change from baseline at 12 months between HRQoL and motor and non-motor symptoms. Results: A total of 195 patients were included. At baseline, HRQoL was moderately positively correlated with Activities of Daily Living (UPDRS II, PCC = 0.44), non-motor symptoms (0.48), and measures of sleep (0.50 and 0.40); all p < 0.001. After 12 months of treatment with LCIG, improvements in HRQoL were moderately positively correlated with improvement from baseline in non-motor symptoms (PCC = 0.42), sleep (0.54), and daytime sleepiness (0.40; all p < 0.001), and weakly correlated with improvement in dyskinesia signs and symptoms (PCC = 0.23; p = 0.011). Improvement in HRQoL was not correlated with improvements in OFF time or dyskinesia time. Conclusion: Both at baseline and for change from baseline at 12 months, HRQoL was correlated with baseline and change from baseline in dyskinesia, Activities of Daily Living, and non-motor symptoms, including sleep; but not with baseline or change in OFF time.en
dc.language.isoenges
dc.publisherIOS Pressen
dc.relation.ispartofJournal of Parkinson's Disease. 2022, V. 12, n. 3, p. 917-926en
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDyskinesiaen
dc.subjectHealth-related quality of lifeen
dc.subjectLevodopa-carbidopa intestinal gelen
dc.subjectNon-motor symptomsen
dc.subjectParkinson’s diseaseen
dc.subject.otherSistema nervioso-Enfermedadeses
dc.subject.otherNervous system-Diseasesen
dc.subject.otherMedicinaes
dc.subject.otherMedicineen
dc.subject.otherNeurologíaes
dc.subject.otherNeurologyen
dc.titleOutcomes Impacting Quality of Life in Advanced Parkinson’s Disease Patients Treated with Levodopa-Carbidopa Intestinal Gelen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://content.iospress.com/articles/journal-of-parkinsons-disease/jpd212979es
dc.identifier.doi10.3233/JPD-212979
dc.identifier.essn1877-718X
dc.journal.titleJournal of Parkinson's Diseaseen
dc.volume.number12es
dc.issue.number3es
dc.page.initial917es
dc.page.final926es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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