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dc.contributor.authorSantos García, Diego
dc.contributor.authorDeus-Fonticoba, Teresa de
dc.contributor.authorCores Bartolomé, Carlos
dc.contributor.authorFeal Painceiras, María
dc.contributor.authorGarcía Díaz, Iago
dc.contributor.authorÍñiguez Alvarado, María Cristina
dc.contributor.authorPaz González, José Manuel
dc.contributor.authorJesús, Silvia
dc.contributor.authorCosgaya, Marina
dc.contributor.authorGarcía Caldentey, Juan
dc.contributor.authorCaballol, Núria
dc.contributor.authorLegarda, Inés
dc.contributor.authorHernández Vara, Jorge
dc.contributor.authorCabo López, Iria
dc.contributor.authorLópez Manzanares, Lydia
dc.contributor.authorGonzález Aramburu, Isabel
dc.contributor.authorÁvila Rivera, María A.
dc.contributor.authorGómez Mayordomo, Víctor
dc.contributor.authorNogueira, Víctor
dc.contributor.authorDotor, Julio
dc.contributor.authorBorrue, Carmen
dc.contributor.authorSolano Vila, Berta
dc.contributor.authorÁlvarez Saúco, María
dc.contributor.authorVela Desojo, Lydia
dc.contributor.authorEscalante Arroyo, Sonia
dc.contributor.authorCubo Delgado, Esther 
dc.contributor.authorMendoza, Zebenzui
dc.contributor.authorMartínez Castrillo, Juan Carlos
dc.contributor.authorSánchez Alonso, Pilar
dc.contributor.authorAlonso Losada, María Gema
dc.contributor.authorLópez Ariztegui, Nuria
dc.contributor.authorGastón, Itziar
dc.contributor.authorKulisevsky Bojarsky, Jaume
dc.contributor.authorSeijo, Manuel
dc.contributor.authorValero, Caridad
dc.contributor.authorAlonso Redondo, Rubén
dc.contributor.authorBuongiorno, María Teresa
dc.contributor.authorOrdás Bandera, Carlos Manuel
dc.contributor.authorMenéndez González, Manuel
dc.contributor.authorMcAfee, Darrian
dc.contributor.authorMartínez Martín, Pablo
dc.contributor.authorMir, Pablo
dc.contributor.authorCOPPADIS Study Group
dc.date.accessioned2024-03-14T12:56:10Z
dc.date.available2024-03-14T12:56:10Z
dc.date.issued2023-11
dc.identifier.issn2162-3279
dc.identifier.urihttp://hdl.handle.net/10259/8825
dc.description.abstractBackground and objective: Recently, we demonstrated that staging Parkinson's disease (PD) with a novel simple classification called MNCD, based on four axes (motor, non-motor, cognition, and dependency) and five stages, correlated with disease severity and patients’ quality of life. Here, we analyzed the correlation of MNCD staging with PD caregiver's status. Patients and methods: Data from the baseline visit of PD patients and their principal caregiver recruited from 35 centers in Spain from the COPPADIS cohort from January 2016 to November 2017 were used to apply the MNCD total score (from 0 to 12) and MNCD stages (from 1 to 5) in this cross-sectional analysis. Caregivers completed the Zarit Caregiver Burden Inventory (ZCBI), Caregiver Strain Index (CSI), Beck Depression Inventory-II (BDI-II), PQ-10, and EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Two hundred and twenty-four PD patients (63 ± 9.6 years old; 61.2% males) and their caregivers (58.5 ± 12.1 years old; 67.9% females) were included. The frequency of MNCD stages was 1, 7.6%; 2, 58.9%; 3, 31.3%; and 4–5, 2.2%. A more advanced MNCD stage was associated with a higher score on the ZCBI (p < .0001) and CSI (p < .0001), and a lower score on the PQ-10 (p = .001), but no significant differences were observed in the BDI-II (p = .310) and EUROHIS-QOL8 (p = .133). Moderate correlations were observed between the MNCD total score and the ZCBI (r = .496; p < .0001), CSI (r = .433; p < .0001), and BDI-II (r = .306; p < .0001) in caregivers. Conclusion: Staging PD according to the MNCD classification is correlated with caregivers’ strain and burden.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherWileyen
dc.relation.ispartofBrain and Behavior. 2023, V. 13, n. 12en
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBurdenen
dc.subjectCaregiveren
dc.subjectNon-motor symptomsen
dc.subjectParkinson’s diseaseen
dc.subjectStageen
dc.subject.otherSistema nervioso-Enfermedadeses
dc.subject.otherNervous system-Diseasesen
dc.subject.otherMedicinaes
dc.subject.otherMedicineen
dc.subject.otherNeurologíaes
dc.subject.otherNeurologyen
dc.titleStaging Parkinson's disease according to the MNCD classification correlates with caregiver burdenen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1002/brb3.3295es
dc.identifier.doi10.1002/brb3.3295
dc.identifier.essn2162-3279
dc.journal.titleBrain and Behavioren
dc.volume.number13es
dc.issue.number12es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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