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dc.contributor.authorSantos García, Diego
dc.contributor.authorDeus-Fonticoba, Teresa de
dc.contributor.authorCores Bartolomé, Carlos
dc.contributor.authorFeal Painceiras, María
dc.contributor.authorÍñiguez Alvarado, María Cristina
dc.contributor.authorGarcía Díaz, Iago
dc.contributor.authorJesús, Silvia
dc.contributor.authorBuongiorno, María Teresa
dc.contributor.authorPlanellás, Lluis L.
dc.contributor.authorCosgaya, Marina
dc.contributor.authorGarcía Caldentey, Juan
dc.contributor.authorCaballol, Núria
dc.contributor.authorLegarda, Inés
dc.contributor.authorHernández Vara, Jorge
dc.contributor.authorCabo López, Iria
dc.contributor.authorLópez Manzanares, Lydia
dc.contributor.authorGonzález Aramburu, Isabel
dc.contributor.authorÁvila Rivera, María A.
dc.contributor.authorGómez Mayordomo, Víctor
dc.contributor.authorNogueira, Víctor
dc.contributor.authorPuente, Víctor
dc.contributor.authorDotor, Julio
dc.contributor.authorBorrue, Carmen
dc.contributor.authorSolano Vila, Berta
dc.contributor.authorÁlvarez Saúco, María
dc.contributor.authorVela Desojo, Lydia
dc.contributor.authorEscalante Arroyo, Sonia
dc.contributor.authorCubo Delgado, Esther 
dc.contributor.authorCarrillo Padilla, Francisco
dc.contributor.authorMartínez Castrillo, Juan Carlos
dc.contributor.authorSánchez Alonso, Pilar
dc.contributor.authorAlonso Losada, María Gema
dc.contributor.authorLópez Ariztegui, Nuria
dc.contributor.authorGastón, Itziar
dc.contributor.authorKulisevsky Bojarsky, Jaume
dc.contributor.authorMenéndez González, Manuel
dc.contributor.authorSeijo, Manuel
dc.contributor.authorRuíz Martínez, Javier
dc.contributor.authorValero, Caridad
dc.contributor.authorKurtis, Mónica M.
dc.contributor.authorGonzález Ardura, Jessica
dc.contributor.authorAlonso Redondo, Rubén
dc.contributor.authorOrdás Bandera, Carlos Manuel
dc.contributor.authorLópez Díaz, Luis M.
dc.contributor.authorMcAfee, Darrian
dc.contributor.authorCalopa, Matilde
dc.contributor.authorCarrillo, Fátima
dc.contributor.authorEscamilla-Sevilla, Francisco
dc.contributor.authorFreire-Alvarez, Eric
dc.contributor.authorGómez Esteban, Juan Carlos
dc.contributor.authorGarcía Ramos, Rocío
dc.contributor.authorLuquin Piudo, Mª Rosario
dc.contributor.authorMartínez Torres, Irene
dc.contributor.authorSesar Ignacio, Ángel
dc.contributor.authorMartínez Martín, Pablo
dc.contributor.authorMir, Pablo
dc.date.accessioned2024-03-14T13:14:13Z
dc.date.available2024-03-14T13:14:13Z
dc.date.issued2023-05
dc.identifier.issn1877-7171
dc.identifier.urihttp://hdl.handle.net/10259/8826
dc.description.abstractBackground: Recently, a novel simple classification called MNCD, based on 4 axes (Motor; Non-motor; Cognition; Dependency) and 5 stages, has been proposed to classify Parkinson's disease (PD). Objective: Our aim was to apply the MNCD classification in a cohort of PD patients for the first time and also to analyze the correlation with quality of life (QoL) and disease severity. Methods: Data from the baseline visit of PD patients recruited from 35 centers in Spain from the COPPADIS cohort fromJanuary 2016 to November 2017 were used to apply the MNCD classification. Three instruments were used to assess QoL:1) the 39-item Parkinson's disease Questionnaire [PDQ-39]); PQ-10; the EUROHIS-QOL 8-item index (EUROHIS-QOL8). Results: Four hundred and thirty-nine PD patients (62.05±7.84 years old; 59% males) were included. MNCD stage was:stage 1, 8.4% (N = 37); stage 2, 62% (N = 272); stage 3, 28.2% (N = 124); stage 4-5, 1.4% (N = 6). A more advancedMNCD stage was associated with a higher score on the PDQ39SI (p < 0.0001) and a lower score on the PQ-10 (p< 0.0001) and EUROHIS-QOL8 (p< 0.0001). In many other aspects of the disease, such as disease duration, levodopa equivalent daily dose, motor symptoms, non-motor symptoms, and autonomy for activities of daily living, an association between the stage and severity was observed, with data indicating a progressive worsening related to disease progression throughout the proposed stages. Conclusion: Staging PD according to the MNCD classification correlated with QoL and disease severity. The MNCD could be a proper tool to monitor the progression of PD.en
dc.description.sponsorshipThe supplementary material is available in the electronic version of this article: https://dx.doi.org/ 10.3233/JPD-225073.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherIOS Pressen
dc.relation.ispartofJournal of Parkinson's Disease. 2023, V. 13, n. 3, p. 379-402en
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectAxial symptomsen
dc.subjectCognitionen
dc.subjectMNCD classificationen
dc.subjectNon-motor symptomsen
dc.subjectParkinson’s diseaseen
dc.subjectQuality of lifeen
dc.subject.otherSistema nervioso-Enfermedadeses
dc.subject.otherNervous system-Diseasesen
dc.subject.otherMedicinaes
dc.subject.otherMedicineen
dc.subject.otherNeurologíaes
dc.subject.otherNeurologyen
dc.titleStaging Parkinson’s Disease According to the MNCD (Motor/Non-motor/Cognition/Dependency) Classification Correlates with Disease Severity and Quality of Lifeen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://content.iospress.com/articles/journal-of-parkinsons-disease/jpd225073es
dc.identifier.doi10.3233/JPD-225073
dc.identifier.essn1877-718X
dc.journal.titleJournal of Parkinson's Diseaseen
dc.volume.number13es
dc.issue.number3es
dc.page.initial379es
dc.page.final402es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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