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dc.contributor.authorSantos García, Diego
dc.contributor.authorLaguna, Ariadna
dc.contributor.authorHernández Vara, Jorge
dc.contributor.authorDeus-Fonticoba, Teresa de
dc.contributor.authorCores Bartolomé, Carlos
dc.contributor.authorFeal Painceiras, María
dc.contributor.authorÍñiguez Alvarado, María Cristina
dc.contributor.authorGarcía Díaz, Iago
dc.contributor.authorJesús, Silvia
dc.contributor.authorBuongiorno, María Teresa
dc.contributor.authorPlanellás, Lluis L.
dc.contributor.authorCosgaya, Marina
dc.contributor.authorGarcía Caldentey, Juan
dc.contributor.authorCaballol, Núria
dc.contributor.authorLegarda, Inés
dc.contributor.authorCabo López, Iria
dc.contributor.authorLópez Manzanares, Lydia
dc.contributor.authorGonzález Aramburu, Isabel
dc.contributor.authorÁvila Rivera, María A.
dc.contributor.authorGómez Mayordomo, Víctor
dc.contributor.authorNogueira, Víctor
dc.contributor.authorPuente, Víctor
dc.contributor.authorDotor, Julio
dc.contributor.authorBorrue, Carmen
dc.contributor.authorSolano Vila, Berta
dc.contributor.authorÁlvarez Saúco, María
dc.contributor.authorVela Desojo, Lydia
dc.contributor.authorEscalante Arroyo, Sonia
dc.contributor.authorCubo Delgado, Esther 
dc.contributor.authorCarrillo Padilla, Francisco
dc.contributor.authorMartínez Castrillo, Juan Carlos
dc.contributor.authorSánchez Alonso, Pilar
dc.contributor.authorAlonso Losada, María Gema
dc.contributor.authorLópez Ariztegui, Nuria
dc.contributor.authorGastón, Itziar
dc.contributor.authorKulisevsky Bojarsky, Jaume
dc.contributor.authorMenéndez González, Manuel
dc.contributor.authorSeijo, Manuel
dc.contributor.authorRuíz Martínez, Javier
dc.contributor.authorValero, Caridad
dc.contributor.authorKurtis, Mónica M.
dc.contributor.authorGonzález Ardura, Jessica
dc.contributor.authorAlonso Redondo, Rubén
dc.contributor.authorOrdás Bandera, Carlos Manuel
dc.contributor.authorLópez Díaz, Luis M.
dc.contributor.authorMcAfee, Darrian
dc.contributor.authorMartínez Martín, Pablo
dc.contributor.authorMir, Pablo
dc.contributor.authorCOPPADIS Study Group
dc.date.accessioned2024-03-15T07:49:26Z
dc.date.available2024-03-15T07:49:26Z
dc.date.issued2023-02
dc.identifier.urihttp://hdl.handle.net/10259/8827
dc.description.abstractBackground and objective: Sex plays a role in Parkinson’s disease (PD) mechanisms. We analyzed sex difference manifestations among Spanish patients with PD. Patients and Methods: PD patients who were recruited from the Spanish cohort COPPADIS from January 2016 to November 2017 were included. A cross-sectional and a two-year follow-up analysis were conducted. Univariate analyses and general linear model repeated measure were used. Results: At baseline, data from 681 PD patients (mean age 62.54 ± 8.93) fit the criteria for analysis. Of them, 410 (60.2%) were males and 271 (39.8%) females. There were no differences between the groups in mean age (62.36 ± 8.73 vs. 62.8 ± 9.24; p = 0.297) or in the time from symptoms onset (5.66 ± 4.65 vs. 5.21 ± 4.11; p = 0.259). Symptoms such as depression (p < 0.0001), fatigue (p < 0.0001), and pain (p < 0.00001) were more frequent and/or severe in females, whereas other symptoms such as hypomimia (p < 0.0001), speech problems (p < 0.0001), rigidity (p < 0.0001), and hypersexuality (p < 0.0001) were more noted in males. Women received a lower levodopa equivalent daily dose (p = 0.002). Perception of quality of life was generally worse in females (PDQ-39, p = 0.002; EUROHIS-QOL8, p = 0.009). After the two-year follow-up, the NMS burden (Non-Motor Symptoms Scale total score) increased more significantly in males (p = 0.012) but the functional capacity (Schwab and England Activities of Daily Living Scale) was more impaired in females (p = 0.001). Conclusion: The present study demonstrates that there are important sex differences in PD. Long-term prospective comparative studies are needed.en
dc.description.sponsorshipCOPPADIS and the present study were developed with the help of Fundación Española de Ayuda a la Investigación en Enfermedades Neurodegenerativas y/o de Origen Genético ( https://fundaciondegen.org/) and Alpha Bioresearch (www.alphabioresearch.com). Also, we received grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Concesión de subvenciones de Proyectos de Investigación en Salud de la convocatoria 2020 de la Acción Estratégica en Salud 2017–2020 por el proyecto “PROGRESIÓN NO MOTORA E IMPACTO EN LA CALIDAD DE VIDA EN LA ENFERMEDAD DE PARKINSON”) to develop a part of the COPPADIS project.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherMDPIen
dc.relation.ispartofJournal of Clinical Medicine. 2023, V. 12, n. 4, 1329en
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMotoren
dc.subjectNon-motor symptomsen
dc.subjectGenderen
dc.subjectParkinson’s diseaseen
dc.subjectQuality of lifeen
dc.subjectSexen
dc.subject.otherSistema nervioso-Enfermedadeses
dc.subject.otherNervous system-Diseasesen
dc.subject.otherMedicinaes
dc.subject.otherMedicineen
dc.subject.otherNeurologíaes
dc.subject.otherNeurologyen
dc.titleSex Differences in Motor and Non-Motor Symptoms among Spanish Patients with Parkinson’s Diseaseen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.3390/jcm12041329es
dc.identifier.doi10.3390/jcm12041329
dc.identifier.essn2077-0383
dc.journal.titleJournal of Clinical Medicineen
dc.volume.number12es
dc.issue.number4es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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