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dc.contributor.authorKim, Jonggeol Jeffrey
dc.contributor.authorVitale, Dan
dc.contributor.authorVéliz Otani, Diego
dc.contributor.authorLian, Michelle Mulan
dc.contributor.authorHeilbron, Karl
dc.contributor.author23andMe Research Team
dc.contributor.authorIwaki, Hirotaka
dc.contributor.authorLake, Julie
dc.contributor.authorWarly Solsberg, Caroline
dc.contributor.authorLeonard, Hampton
dc.contributor.authorMakarious, Mary B.
dc.contributor.authorTan, Eng-King
dc.contributor.authorSingleton, Andrew B.
dc.contributor.authorBandres-Ciga, Sara
dc.contributor.authorNoyce, Alastair J.
dc.contributor.authorCubo Delgado, Esther 
dc.contributor.authorGlobal Parkinson's Genetics Program
dc.contributor.authorBlauwendraat, Cornelis
dc.contributor.authorNalls, Mike A.
dc.contributor.authorNee Foo, Jia
dc.contributor.authorMata, Ignacio
dc.date.accessioned2024-03-20T11:57:55Z
dc.date.available2024-03-20T11:57:55Z
dc.date.issued2023-12
dc.identifier.issn1546-1718
dc.identifier.urihttp://hdl.handle.net/10259/8858
dc.description.abstractAlthough over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, most studies have been performed in just one population at a time. Here we performed a large-scale multi-ancestry meta-analysis of Parkinson’s disease with 49,049 cases, 18,785 proxy cases and 2,458,063 controls including individuals of European, East Asian, Latin American and African ancestry. In a meta-analysis, we identified 78 independent genome-wide significant loci, including 12 potentially novel loci (MTF2, PIK3CA, ADD1, SYBU, IRS2, USP8, PIGL, FASN, MYLK2, USP25, EP300 and PPP6R2) and fine-mapped 6 putative causal variants at 6 known PD loci. By combining our results with publicly available eQTL data, we identified 25 putative risk genes in these novel loci whose expression is associated with PD risk. This work lays the groundwork for future efforts aimed at identifying PD loci in non-European populations.en
dc.format.mimetypeapplication/pdf
dc.language.isoenges
dc.publisherSpringer Natureen
dc.relation.ispartofNature Genetics. 2024, V. 56, n. 1, p. 27-36en
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.otherSistema nervioso-Enfermedadeses
dc.subject.otherNervous system-Diseasesen
dc.subject.otherMedicinaes
dc.subject.otherMedicineen
dc.subject.otherNeurologíaes
dc.subject.otherNeurologyen
dc.titleMulti-ancestry genome-wide association meta-analysis of Parkinson’s diseaseen
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.relation.publisherversionhttps://doi.org/10.1038/s41588-023-01584-8es
dc.identifier.doi10.1038/s41588-023-01584-8
dc.identifier.essn1061-4036
dc.journal.titleNature Geneticsen
dc.volume.number56es
dc.issue.number1es
dc.page.initial27es
dc.page.final36es
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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