RT info:eu-repo/semantics/article
T1 Dynamic energy budget approach to evaluate antibiotic effects on biofilms
A1 Birnir, Bjorn
A1 Carpio, Ana
A1 Cebrián de Barrio, Elena
A1 Vidal, Perfecto
K1 Dynamic energy budget
K1 Bacterial biofilm
K1 Antibiotic
K1 Numerical simulation
K1 Microbiología
K1 Microbiology
K1 Matemáticas
K1 Mathematics
AB Quantifying the action of antibiotics on biofilms is essential to devise therapies against chronic infections. Biofilms are bacterial communities attached to moist surfaces, sheltered from external aggressions by a polymeric matrix. Coupling a dynamic energy budget based description of cell metabolism to surrounding concentration fields, we are able to approximate survival curves measured for different antibiotics. We reproduce numerically stratified distributions of cell types within the biofilm and introduce ways to incorporate different resistance mechanisms. Qualitative predictions follow that are in agreement with experimental observations, such as higher survival rates of cells close to the substratum when employing antibiotics targeting active cells or enhanced polymer production when antibiotics are administered. The current computational model enables validation and hypothesis testing when developing therapies.
PB Elsevier
SN 1007-5704
YR 2018
FD 2018
LK http://hdl.handle.net/10259/8269
UL http://hdl.handle.net/10259/8269
LA eng
NO Research partially supported by the NILS Mobility Program grant No. 001-ABELIM-2013 through the EEA financial mechanism and MINECO grant No. MTM2014-56948-C2-1-P.
DS Repositorio Institucional de la Universidad de Burgos
RD 09-may-2024