RT info:eu-repo/semantics/article
T1 NMR-Based Metabolomics Approach to Explore Brain Metabolic Changes Induced by Prenatal Exposure to Autism-Inducing Chemicals
A1 Abreu, Ana Cristina
A1 Morales Navas, Miguel
A1 Pérez Fernández, Cristian
A1 Sánchez Santed, Fernando
A1 Fernández, Ignacio
K1 Fisiología
K1 Physiology
K1 Química física
K1 Chemistry, Physical and theoretical
K1 Psicología
K1 Psychology
K1 Salud
K1 Health
AB NMR offers the unique potential to holistically screen hundreds of metabolites and has already proved to be a powerful technique able to provide a global picture of a wide range of metabolic processes underlying complex and multifactorial diseases, such as neurodegenerative and neurodevelopmental diseases. The aim of this study was to apply an NMR-based metabolomics approach to explore brain metabolic changes in both male and female rats induced by prenatal exposure to two chemicals associated with autism disorders—the organophosphorus pesticide chlorpyrifos (CPF) and the antiepileptic drug valproic acid (VPA)—at different postnatal ages. Depending on the age and on the brain region (hippocampus and cerebellum), several metabolites were shown to be significantly affected by exposure to both compounds. The evaluation of the spectral profiles revealed that the nervous-system-specific metabolite N-acetylaspartate (NAA), amino acid neurotransmitters (e.g., glutamate, glutamine, GABA, glycine), pyroglutamic acid, unsaturated fatty acids, and choline-based compounds are discriminant biomarkers. Additionally, metabolic changes varied as a function of age, but importantly not of sex.
PB American Chemical Society
SN 1554-8929
YR 2021
FD 2021
LK http://hdl.handle.net/10259/8561
UL http://hdl.handle.net/10259/8561
LA eng
NO This research has been funded by the by the State Research Agency (projects RTC-2016-5239-2, CTQ2017-84334-R, and PSI2017-86847-C2-1-R) of the Spanish Ministry of Science, Innovation and Universities and EU FEDER funds. A.C.A. thanks University of Almería for a postdoctoral Hipatia fellowship.
DS Repositorio Institucional de la Universidad de Burgos
RD 15-may-2024