RT info:eu-repo/semantics/article
T1 Pesticides and aging: Preweaning exposure to Chlorpyrifos induces a general hypomotricity state in late-adult rats
A1 Pérez Fernández, Cristian
A1 Morales Navas, Miguel
A1 Guardia Escote, Laia
A1 Colomina, María Teresa
A1 Giménez, Estela
A1 Sánchez Santed, Fernando
K1 Organophosphates
K1 Chlorpyrifos
K1 Spatial memory
K1 Compulsivity
K1 Anxiety
K1 Old age
K1 Fisiología
K1 Physiology
K1 Química física
K1 Chemistry, Physical and theoretical
K1 Psicología
K1 Psychology
K1 Salud
K1 Health
AB The molecular and behavioral effects of the developmental exposure to low doses of Chlorpyrifos (CPF) have been intensively studied in young (neonates and adolescents), and adult animals. However, no study examined influences of developmental CPF exposure in older adult or geriatric rats. This is relevant as such ages are generally linked to cognitive decline and the onset of specific neurodegenerative disorders, some of them previously associated with CPF exposure in both preclinical and human studies. 1 mg/kg/mL of CPF was orally administered to both male and female Wistar rats from Postnatal day 10 to 15. Animals’ spatial memory, learning, compulsivity, motricity, and anxiety were analyzed with Morris Water Maze (15–16 months of age) and the Plus-maze (at 18 months of age). Results showed that postnatal CPF exposure did not alter either spatial memory, compulsive-like behaviors, or anxiety levels in late-adult rats. However, CPF exposed rats were hyposensitive to brief disruptions (Probe stage) following the learning phase and showed a general decrease in locomotor activity in both paradigms. These data are relevant as it is the first time that developmental exposure to CPF has been studied at such a late age, observing important effects in locomotor activity that could be linked to specific pathologies previously associated with CPF effects in people. Future studies should extend these findings to other behaviors and molecular outcomes.
PB Elsevier
SN 0161-813X
YR 2021
FD 2021
LK http://hdl.handle.net/10259/8563
UL http://hdl.handle.net/10259/8563
LA eng
NO This study was supported by two grants from the Ministerio de Economía y Competitividad, Spanish Government and the Fondo Europeo de Desarrollo Regional (MINECOFEDER). Grant numbers: PSI2017-86847-C2-1-R MINECO-FEDER and PSI2017-86847-C2-2-R.
DS Repositorio Institucional de la Universidad de Burgos
RD 16-may-2024