RT info:eu-repo/semantics/article
T1 Is Restless Legs Syndrome Associated with an Increased Risk of Mortality? A Meta-Analysis of Cohort Studies
A1 Cubo Delgado, Esther
A1 Gallego Nieto, César
A1 Elizari Roncal, Miren
A1 Barroso Pérez, Mª Teresa
A1 Collazo Riobó, Carla
A1 Delgado López, Pedro David
K1 Restless legs syndrome
K1 Mortality
K1 Survival
K1 Epidemiology
K1 Cohorts
K1 Sleep disorder
K1 Sistema nervioso-Enfermedades
K1 Nervous system-Diseases
K1 Neurología
K1 Neurology
K1 Medicina
K1 Medicine
AB Background: Restless legs syndrome (RLS) is a common sleep disorder,. although controversial, growing evidence relates the presence of RLS to an increased risk of mortality, mainly due to cardiovascular events. The aim of this article was to review the role of RLS as a risk factor of mortality according to independent cohort studies.Methods: We performed a literature review via PubMed database for articles relating RLS and mortality. We used the random-effects model to calculate the pooled effect estimates on mortality. Heterogeneity between studies was assessed using quantitative and qualitative analysis.Results: Out of 100 articles identified, 13 were finally included. Although studies were heterogeneous (p = 0.001), no significant publication bias was found. When all cohort studies were considered, the random-effects model yielded a significantly increased risk of mortality in RLS versus non-RLS patients (13 studies, hazard ratio [HR] = 1.52, 95% confidence interval [CI] 1.28–1.80). However, this association was not statistically significant when only cohort studies using the international RLS diagnostic criteria were considered (5 studies, HR = 1.63, 95% CI 0.94–2.81).Discussion: The results of this meta-analysis suggest that RLS seems to be a risk factor of mortality, although this association is conditioned by the diagnostic criteria used in the studies. Future long-term follow-up standardized mortality studies are needed to address this important question that carries potential impact on population global health.
PB Ubiquity Press
YR 2019
FD 2019-07
LK http://hdl.handle.net/10259/8787
UL http://hdl.handle.net/10259/8787
LA eng
NO Artículo de revisión
NO This work was supported by a grant from the Castilla y Leon Health Department (GRS 1764/A/18).
DS Repositorio Institucional de la Universidad de Burgos
RD 09-may-2024