RT info:eu-repo/semantics/article
T1 Non-motor symptom burden in patients with Parkinson’s disease with impulse control disorders and compulsive behaviours: results from the COPPADIS cohort
A1 Jesús, Silvia
A1 Labrador Espinosa, Miguel A.
A1 Adarmes Gómez, Astrid D.
A1 Méndel del Barrio, C.
A1 Martínez Castrillo, Juan Carlos
A1 Alonso Cánovas, Araceli
A1 Sánchez Alonso, Pilar
A1 Novo Pontes, Sabela
A1 Alonso Losada, María Gema
A1 López Ariztegui, Nuria
A1 Segundo Rodríguez, José Clemente
A1 Morales, M. I.
A1 Gastón, Itziar
A1 Lacruz Bescos, F.
A1 Clavero Ibarra, Pedro
A1 Kulisevsky Bojarsky, Jaume
A1 Pagonabarraga, Javier
A1 Pascual Sedano, Berta
A1 Martínez Martín, Pablo
A1 Santos García, Diego
A1 Mir, Pablo
A1 Cubo Delgado, Esther
A1 COPPADIS Study Group
K1 Sistema nervioso-Enfermedades
K1 Nervous system-Diseases
K1 Medicina
K1 Medicine
K1 Neurología
K1 Neurology
AB The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson’s disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose.
PB Springer Nature
YR 2020
FD 2020-10
LK http://hdl.handle.net/10259/8793
UL http://hdl.handle.net/10259/8793
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 12-may-2024