RT info:eu-repo/semantics/article
T1 Predictors of Global Non-Motor Symptoms Burden Progression in Parkinson’s Disease. Results from the COPPADIS Cohort at 2-Year Follow-Up
A1 Santos García, Diego
A1 Deus-Fonticoba, Teresa de
A1 Cores Bartolomé, Carlos
A1 Canfield, Héctor
A1 Paz González, José Manuel
A1 Martínez Miró, Cristina
A1 Valdés Aymerich, Lorena
A1 Suárez Castro, Ester
A1 Jesús, Silvia
A1 Aguilar, Miquel
A1 Pastor, Pau
A1 Planellás, Lluis L.
A1 Cosgaya, Marina
A1 García Caldentey, Juan
A1 Caballol, Núria
A1 Legarda, Inés
A1 Hernández Vara, Jorge
A1 Cabo López, Iria
A1 López Manzanares, Lydia
A1 González Aramburu, Isabel
A1 Ávila Rivera, María A.
A1 Catalán, María José
A1 Nogueira, Víctor
A1 Puente, Víctor
A1 Dotor, Julio
A1 Borrue, Carmen
A1 Solano, Berta
A1 Álvarez Saúco, María
A1 Vela Desojo, Lydia
A1 Escalante Arroyo, Sonia
A1 Cubo Delgado, Esther
A1 Carrillo Padilla, Francisco
A1 Martínez Castrillo, Juan Carlos
A1 Sánchez Alonso, Pilar
A1 Alonso Losada, María Gema
A1 López Ariztegui, Nuria
A1 Gastón, Itziar
A1 Kulisevsky Bojarsky, Jaume
A1 Blázquez Estrada, Marta
A1 Seijo, Manuel
A1 Ruíz Martínez, Javier
A1 Valero, Caridad
A1 Kurtis, Mónica M.
A1 Fabregues, Oriol de
A1 González Ardura, Jessica
A1 Alonso Redondo, Rubén
A1 Ordás Bandera, Carlos Manuel
A1 López Díaz, Luis M.
A1 McAfee, Darrian
A1 Martínez Martín, Pablo
A1 Mir, Pablo
A1 COPPADIS Study Group
K1 Mood
K1 Non-motor symptoms
K1 Parkinson’s disease
K1 Progression
K1 Quality of life
K1 Sistema nervioso-Enfermedades
K1 Nervous system-Diseases
K1 Medicina
K1 Medicine
K1 Neurología
K1 Neurology
AB Background and Objective: Non-motor symptoms (NMS) progress in different ways between Parkinson’s disease (PD) patients. The aim of the present study was to (1) analyze the change in global NMS burden in a PD cohort after a 2-year follow-up, (2) to compare the changes with a control group, and (3) to identify predictors of global NMS burden progression in the PD group. Material and Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort from January 2016 to November 2017, were followed-up with after 2 years. The Non-Motor Symptoms Scale (NMSS) was administered at baseline (V0) and at 24 months ± 1 month (V2). Linear regression models were used for determining predictive factors of global NMS burden progression (NMSS total score change from V0 to V2 as dependent variable). Results: After the 2-year follow-up, the mean NMS burden (NMSS total score) significantly increased in PD patients by 18.8% (from 45.08 ± 37.62 to 53.55 ± 42.28; p < 0.0001; N = 501; 60.2% males, mean age 62.59 ± 8.91) compared to no change observed in controls (from 14.74 ± 18.72 to 14.65 ± 21.82; p = 0.428; N = 122; 49.5% males, mean age 60.99 ± 8.32) (p < 0.0001). NMSS total score at baseline (β = −0.52), change from V0 to V2 in PDSS (Parkinson’s Disease Sleep Scale) (β = −0.34), and change from V0 to V2 in NPI (Neuropsychiatric Inventory) (β = 0.25) provided the highest contributions to the model (adjusted R-squared 0.41; Durbin-Watson test = 1.865). Conclusions: Global NMS burden demonstrates short-term progression in PD patients but not in controls and identifies worsening sleep problems and neuropsychiatric symptoms as significant independent predictors of this NMS progression.
PB MDPI
YR 2021
FD 2021-06
LK http://hdl.handle.net/10259/8805
UL http://hdl.handle.net/10259/8805
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 11-may-2024