RT info:eu-repo/semantics/article
T1 Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease
A1 Martínez-Horta, Saul
A1 Berj-Kasem, Helena
A1 Horta-Barba, Andrea
A1 Pascual Sedano, Berta
A1 Santos García, Diego
A1 Deus-Fonticoba, Teresa de
A1 Jesús, Silvia
A1 Aguilar, Miquel
A1 Planellás, Lluis L.
A1 García Caldentey, Juan
A1 Caballol, Núria
A1 Vives Pastor, Bárbara
A1 Hernández Vara, Jorge
A1 Cabo López, Iria
A1 López Manzanares, Lydia
A1 González Aramburu, Isabel
A1 Ávila Rivera, María A.
A1 Catalán, María José
A1 López Díaz, Luis M.
A1 Puente, Víctor
A1 García Moreno, José Manuel
A1 Borrue, Carmen
A1 Solano Vila, Berta
A1 Álvarez Saúco, María
A1 Vela Desojo, Lydia
A1 Escalante Arroyo, Sonia
A1 Cubo Delgado, Esther
A1 Carrillo Padilla, Francisco
A1 Martínez Castrillo, Juan Carlos
A1 Sánchez Alonso, Pilar
A1 Alonso Losada, María Gema
A1 López Ariztegui, Nuria
A1 Gastón, Itziar
A1 Blázquez Estrada, Marta
A1 Seijo, Manuel
A1 Ruíz Martínez, Javier
A1 Valero, Caridad
A1 Kurtis, Mónica M.
A1 Fabregues, Oriol de
A1 González Ardura, Jessica
A1 Prieto Jurczynska, Cristina
A1 Martínez Martín, Pablo
A1 Mir, Pablo
A1 Kulisevsky Bojarsky, Jaume
A1 COPPADIS Study Group
K1 Parkinson’s disease
K1 PD-MCI
K1 Cognition
K1 Lifestyle
K1 Coppadis
K1 Sistema nervioso-Enfermedades
K1 Nervous system-Diseases
K1 Medicina
K1 Medicine
K1 Neurología
K1 Neurology
AB Background: Identifying modifable risk factors for cognitive impairment in the early stages of Parkinson’s disease(PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitivetrials.Methods: Using a standard approach for the assessment of global cognition in PD and controlling for the efects ofage, education and disease duration, we explored the associations between cognitive status, comorbidities, meta‑bolic variables and lifestyle variables in 533 PD participants from the COPPADIS study.Results: Among the overall sample, 21% of participants were classifed as PD-MCI (n=114) and 4% as PDD (n=26).The prevalence of hypertension, diabetes and dyslipidemia was signifcantly higher in cognitively impaired patientswhile no between-group diferences were found for smoking, alcohol intake or use of supplementary vitamins. Bet‑ter cognitive scores were signifcantly associated with regular physical exercise (p<0.05) and cognitive stimulation(<0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p<0.05), Il6 (p<0.05), iron (p<0.05),and homocysteine (p<0.005) levels, and positively associated with vitamin B12 levels (p<0.005).Conclusions: We extend previous fndings regarding the positive and negative infuence of various comorbiditiesand lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially
PB Springer Nature
YR 2021
FD 2021-12
LK http://hdl.handle.net/10259/8809
UL http://hdl.handle.net/10259/8809
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 09-may-2024