RT info:eu-repo/semantics/article
T1 Outcomes Impacting Quality of Life in Advanced Parkinson’s Disease Patients Treated with Levodopa-Carbidopa Intestinal Gel
A1 Kovács, Norbert
A1 Bergmann, Lars
A1 Anca-Herschkovitsch, Marieta
A1 Cubo Delgado, Esther
A1 Davis, Thomas L.
A1 Iansek, Robert
A1 Siddiqui, Mustafa S.
A1 Simu, Mihaela
A1 Standaert, David G.
A1 Chaudhuri, K. Ray
A1 Bourgeois, Paul
A1 Gao, Tianming
A1 Kukreja, Pavnit
A1 Pontieri, Francesco E.
A1 Aldred, Jason
K1 Dyskinesia
K1 Health-related quality of life
K1 Levodopa-carbidopa intestinal gel
K1 Non-motor symptoms
K1 Parkinson’s disease
K1 Sistema nervioso-Enfermedades
K1 Nervous system-Diseases
K1 Medicina
K1 Medicine
K1 Neurología
K1 Neurology
AB Background:It is believed that motor symptoms, including dyskinesia, and non-motor symptoms impact health-related quality of life (HRQoL) in patients with Parkinson’s disease (PD), and that improvements in these metrics are correlated.Objective:Investigate the relationship between HRQoL and measures of PD severity and treatment efficacy, including motor and non-motor symptoms.Methods:This was a planned investigation of an international, prospective, single-arm, post-marketing observational study of the long-term effectiveness of levodopa-carbidopa intestinal gel (LCIG) in patients with advanced PD. Pearson correlation coefficients (PCC) were calculated for baseline and change from baseline at 12 months between HRQoL and motor and non-motor symptoms.Results:A total of 195 patients were included. At baseline, HRQoL was moderately positively correlated with Activities of Daily Living (UPDRS II, PCC = 0.44), non-motor symptoms (0.48), and measures of sleep (0.50 and 0.40); all p < 0.001. After 12 months of treatment with LCIG, improvements in HRQoL were moderately positively correlated with improvement from baseline in non-motor symptoms (PCC = 0.42), sleep (0.54), and daytime sleepiness (0.40; all p < 0.001), and weakly correlated with improvement in dyskinesia signs and symptoms (PCC = 0.23; p = 0.011). Improvement in HRQoL was not correlated with improvements in OFF time or dyskinesia time.Conclusion:Both at baseline and for change from baseline at 12 months, HRQoL was correlated with baseline and change from baseline in dyskinesia, Activities of Daily Living, and non-motor symptoms, including sleep; but not with baseline or change in OFF time.
PB IOS Press
SN 1877-7171
YR 2022
FD 2022-04
LK http://hdl.handle.net/10259/8820
UL http://hdl.handle.net/10259/8820
LA eng
DS Repositorio Institucional de la Universidad de Burgos
RD 10-may-2024