RT info:eu-repo/semantics/article
T1 Risk of Cognitive Impairment in Patients With Parkinson’s Disease With Visual Hallucinations and Subjective Cognitive Complaints
A1 Santos García, Diego
A1 Deus-Fonticoba, Teresa de
A1 Cores Bartolomé, Carlos
A1 Feal Painceiras, María
A1 Paz González, José Manuel
A1 Martínez Miró, Cristina
A1 Jesús, Silvia
A1 Aguilar, Miquel
A1 Pastor, Pau
A1 Planellás, Lluis L.
A1 Cosgaya, Marina
A1 García Caldentey, Juan
A1 Caballol, Núria
A1 Legarda, Inés
A1 Hernández Vara, Jorge
A1 Cabo López, Iria
A1 López Manzanares, Lydia
A1 González Aramburu, Isabel
A1 Ávila Rivera, María A.
A1 Gómez Mayordomo, Víctor
A1 Nogueira, Víctor
A1 Puente, Víctor
A1 Dotor, Julio
A1 Borrue, Carmen
A1 Solano Vila, Berta
A1 Álvarez Saúco, María
A1 Vela Desojo, Lydia
A1 Escalante Arroyo, Sonia
A1 Cubo Delgado, Esther
A1 Carrillo Padilla, Francisco
A1 Martínez Castrillo, Juan Carlos
A1 Sánchez Alonso, Pilar
A1 Alonso Losada, María Gema
A1 López Ariztegui, Nuria
A1 Gastón, Itziar
A1 Kulisevsky Bojarsky, Jaume
A1 Blázquez Estrada, Marta
A1 Seijo, Manuel
A1 Ruíz Martínez, Javier
A1 Valero, Caridad
A1 Kurtis, Mónica M.
A1 Fabregues, Oriol de
A1 González Ardura, Jessica
A1 Alonso Redondo, Rubén
A1 Ordás Bandera, Carlos Manuel
A1 López Díaz, Luis M.
A1 McAfee, Darrian
A1 Martínez Martín, Pablo
A1 Mir, Pablo
A1 COPPADIS Study Group
K1 Cognitive impairment
K1 Dementia
K1 Parkinson’s disease
K1 Subjective cognitive complaints
K1 Visual hallucinations
K1 Sistema nervioso-Enfermedades
K1 Nervous system-Diseases
K1 Medicina
K1 Medicine
K1 Neurología
K1 Neurology
AB Background and Purpose: Visual hallucinations (VH) and subjective cognitive complaints (SCC) are associated with cognitive impairment (CI) in Parkinson’s disease. Our aims were to determine the association between VH and SCC and the risk of CI development in a cohort of patients with Parkinson’s disease and normal cognition (PD-NC).Methods: Patients with PD-NC (total score of >80 on the Parkinson’s Disease Cognitive Rating Scale [PD-CRS]) recruited from the Spanish COPPADIS cohort from January 2016 to November 2017 were followed up after 2 years. Subjects with a score of ≥1 on domain 5 and item 13 of the Non-Motor Symptoms Scale at baseline (V0) were considered as “with SCC” and “with VH,” respectively. CI at the 2-year follow-up (plus or minus 1 month) (V2) was defined as a PD-CRS total score of <81.Results: At V0 (n=376, 58.2% males, age 61.14±8.73 years [mean±SD]), the frequencies of VH and SCC were 13.6% and 62.2%, respectively. VH were more frequent in patients with SCC than in those without: 18.8% (44/234) vs 4.9% (7/142), p<0.0001. At V2, 15.2% (57/376) of the patients had developed CI. VH presenting at V0 was associated with a higher risk of CI at V2 (odds ratio [OR]=2.68, 95% confidence interval=1.05–6.83, p=0.0.039) after controlling for the effects of age, disease duration, education, medication, motor and nonmotor status, mood, and PD-CRS total score at V0. Although SCC were not associated with CI at V2, presenting both VH and SCC at V0 increased the probability of having CI at V2 (OR=3.71, 95% confidence interval=1.36–10.17, p=0.011).Conclusions: VH were associated with the development of SCC and CI at the 2-year follow-up in patients with PD-NC.
PB Korean Neurological Association
SN 1738-6586
YR 2023
FD 2023-01
LK http://hdl.handle.net/10259/8829
UL http://hdl.handle.net/10259/8829
LA eng
NO The resources obtained for the development of this project have been obtained by the Degen Foundation (https://fundaciondegen.org/). A part of the Project is financed with grants from the Spanish Ministry of Economy and Competitiveness [PI16/01575] co-founded by ISCIII (Concesión de subvenciones de Proyectos de Investigación en Salud de la convocatoria 2020 de la Acción Estratégica en Salud 2017-2020 por el proyecto “PROGRESIÓN NO MOTORA E IMPACTO EN LA CALIDAD DE VIDA EN LA ENFERMEDAD DE PARKINSON”).
DS Repositorio Institucional de la Universidad de Burgos
RD 09-may-2024