Universidad de Burgos Repositorio Repositorio
Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/4966

Ver estadísticas de uso
Título : Chloro-Furanocembranolides from Leptogorgia sp. Improve Pancreatic Beta-Cell Proliferation
Autor : Villa Pérez, Pablo .
Gallardo, Amalia B. .
Díaz Marrero, Ana R. .
Rosa, José M. de la .
Croz, Luis D’ .
Perdomo Hernández, Germán M.
Cózar Castellano, Irene .
Darias, José .
Cueto, Mercedes .
Publicado en: Marine Drugs. 2018, V. 16, n. 2, art. 49
Editorial : MDPI
Fecha de publicación : feb-2018
ISSN : 1660-3397
DOI: 10.3390/md16020049
Resumen : Type 2 diabetes (T2DM) is a complex disease linked to pancreatic beta-cell failure and insulin resistance. Current antidiabetic treatment regimens for T2DM include insulin sensitizers and insulin secretagogues. We have previously demonstrated that leptolide, a member of the furanocembranolides family, promotes pancreatic beta-cell proliferation in mice. Considering the beneficial effects of leptolide in diabetic mice, in this study, we aimed to address the capability of leptolide to improve insulin resistance associated with the pathology of obesity. To this end, we tested the hypothesis that leptolide should protect against fatty acid-induced insulin resistance in hepatocytes. In a time-dependent manner, leptolide (0.1 µM) augmented insulin-stimulated phosphorylation of protein kinase B (PKB) by two-fold above vehicle-treated HepG2 cells. In addition, leptolide (0.1 µM) counteracted palmitate-induced insulin resistance by augmenting by four-fold insulin-stimulated phosphorylation of PKB in HepG2 cells. In vivo, acute intraperitoneal administration of leptolide (0.1 mg/kg and 1 mg/kg) improved glucose tolerance and insulin sensitivity in lean mice. Likewise, prolonged leptolide treatment (0.1 mg/kg) in diet-induced obese mice improved insulin sensitivity. These effects were paralleled with an ~50% increased of insulin-stimulated phosphorylation of PKB in liver and skeletal muscle and reduced circulating pro-inflammatory cytokines in obese mice. We concluded that leptolide significantly improves insulin sensitivity in vitro and in obese mice, suggesting that leptolide may be another potential treatment for T2DM
Palabras clave: Leptogorgia
cembranolides
furanocembranolides
diketocembranolides
seco-furanocembranolides
chloro-furanocembranolides
pancreatic beta-cells
Materia: Endocrinología
Endocrinology
Licencia: http://creativecommons.org/licenses/by/4.0/
URI : http://hdl.handle.net/10259/4966
Versión del editor: https://doi.org/10.3390/md16020049
Aparece en las colecciones: Artículos DIABO-TER

Ficheros en este ítem:

Fichero Descripción Tamaño Formato
Gallardo-md_2018.pdf963,42 kBAdobe PDFVisualizar/Abrir

Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons
Creative Commons

Los ítems del Repositorio Institucional de la Universidad de Burgos están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2008 MIT and Hewlett-Packard - Sobre DSpace