The development of abnormal scars has a great impact on people’s well-being, and improv-
ing scarring outcomes after surgery is a field that currently lacks consensus. This review aims to
identify newly researched approaches to improving the quality of surgical scars. A systematic search
of PubMed, Scopus, Web of Science, and ScienceDirect was conducted between 13 May 2023 and
17 May 2023, in accordance with the recommendations of the PRISMA Statement. Study selection
and analysis of methodological quality were performed in parts, independently and blindly, based
on eligibility criteria. The 21 prospective, comparative, and randomized studies reviewed included
1057 subjects and studied approaches such as topical applications of creams with herbal extracts and
silicone gels, growth factors, negative pressure dressings, oligonucleotides, intralesional injection of
compounds such as botulinum toxin, skin closure techniques such as suturing and tissue adhesive,
and laser treatments. There are recent research techniques that generate good results and are really
promising to improve the results of surgical scars; however, the available evidence is extremely
limited in some cases, and it is necessary to deepen its analysis to obtain reliable action protocols in
each type of surgery.
