1,3-Dien-5-ynes have been extensively used as starting materials for the
synthesis of a wide number of different carbo- and heterocycles. The aim of this review is
to give an overview of their utility in organic synthesis, highlighting the variety of
compounds that can be directly accessed from single reactions over these systems. Thus,
cycloaromatization processes are initially commented, followed by reactions directed
toward the syntheses of five-membered rings, other carbocycles and, finally, heterocycles.
The diverse methodologies that have been developed for the synthesis of each of these
types of compounds from 1,3-dien-5-ynes are presented, emphasizing the influence of
the reaction conditions and the use of additional reagents in the outcome of the
transformations.
