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    Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10259/4866

    Título
    Colonization of electrospun polycaprolactone fibers by relevant pathogenic bacterial strains
    Autor
    Rumbo Lorenzo, CarlosAutoridad UBU Orcid
    Tamayo Ramos, Juan AntonioAutoridad UBU Orcid
    Caso, Federica
    Rinaldi, Antonio
    Romero Santacreu, LorenaAutoridad UBU
    Quesada Pato, RobertoAutoridad UBU Orcid
    Cuesta López, SantiagoAutoridad UBU Orcid
    Publicado en
    ACS Applied Materials & Interfaces. 2018, V. 10, n. 14, p. 11467–11473
    Editorial
    American Chemical Society
    Fecha de publicación
    2018-04
    ISSN
    1944-8244
    DOI
    10.1021/acsami.7b19440
    Resumo
    Electrospun biodegradable polymers have emerged as promising materials for their applications in several fields, including biomedicine and food industry. For this reason, the susceptibility of these materials to be colonized by different pathogens is a critical issue for public health, and their study can provide future knowledge to develop new strategies against bacterial infections. In this work, the ability of three pathogenic bacterial species (Pseudomonas aeruginosa, Acinetobacter baumannii, and Listeria monocytogenes) to adhere and form biofilm in electrospun polycaprolactone (PCL) microfibrous meshes was investigated. Bacterial attachment was analyzed in meshes with different microstructure, and comparisons with other materials (borosilicate glass and electrospun polylactic acid (PLA)) fibers were assessed. Analysis included colony forming unit (CFU) counts, scanning electron microscopy (SEM), and crystal violet (CV) staining. All the obtained data suggest that PCL meshes, regardless of their microstructure, are highly susceptible to be colonized by the pathogenic relevant bacteria used in this study, so a pretreatment or a functionalization with compounds that present some antimicrobial activity or antibiofilm properties is highly recommended before their application. Moreover, an experiment designed to simulate a chronic wound environment was used to demonstrate the ability of these meshes to detach biofilms from the substratum where they have developed, thus making them promising candidates to be used in wound cleaning and disinfection.
    Palabras clave
    bacterial attachment
    biofilm
    electrospun polycaprolactone
    foodborne pathogens
    microfibers
    nosocomial pathogens
    Materia
    Química orgánica
    Chemistry, Organic
    Materiales
    Materials
    URI
    http://hdl.handle.net/10259/4866
    Versión del editor
    https://doi.org/10.1021/acsami.7b19440
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